Bioavailability of indomethacin in liposomes.

The research concerned the influence of the liposomally-entrapped indomethacin on its absorption after intragastric administration to rats. It was found that the indomethacin entrapped in liposomes has a favorable influence on the bioavailability in comparison to sole indomethacin suspension.

[Bioavailability of griseofulvin in the form of liposomes].

Liposomes containing griseofulvin have been prepared by shaking method. Lecithin and cholesterol were used to compose phospholipid bilayer of liposomes. The suspension of liposomes in 0.

[The effect of entrapment of procaine hydrochloride in liposomes on its local anesthetic action].

The study has shown the effect of liposomally entrapped procaine hydrochloride on local anaesthesia and its intensity after intradermal administration. The experiments of anaesthetic infiltration have been carried out on guinea pig skin applying mechanical stimulus. Liposomes were prepared by the shaking method followed by suspending in phosphate buffer pH 7.

[The bioavailability of dipyridamole in the form of liposomes].

Liposomes containing dipyridamole have been prepared by evaporating-shaking method. Phospholipid bilayer consisted of lecithin and cholesterol in three varying molar rations: 5:2, 7:2, 10:2. According to lipid layer composition the obtained liposomes varied in size and amount of dipyridamole entrapped.