The development of non-destructive sampling methods of parchment skins for genetic species identification.

Parchment, the skins of animals prepared for use as writing surfaces, offers a valuable source of genetic information. Many have clearly defined provenance, allowing for the genetic findings to be evaluated in temporal and spatial context. While these documents can yield evidence of the animal sources, the DNA contained within these aged skins is often damaged and fragmented.

Backpack-mediated anti-inflammatory macrophage cell therapy for the treatment of traumatic brain injury.

Traumatic brain injury (TBI) is a debilitating disease with no current therapies outside of acute clinical management. While acute, controlled inflammation is important for debris clearance and regeneration after injury, chronic, rampant inflammation plays a significant adverse role in the pathophysiology of secondary brain injury. Immune cell therapies hold unique therapeutic potential for inflammation modulation, due to their active sensing and migration abilities.

2-Photon imaging of fluorescent proteins in living swine.

A common point of failure in translation of preclinical neurological research to successful clinical trials comes in the giant leap from rodent models to humans. Non-human primates are phylogenetically close to humans, but cost and ethical considerations prohibit their widespread usage in preclinical trials. Swine have large, gyrencencephalic brains, which are biofidelic to human brains.

2-Photon imaging of fluorescent proteins in living swine.

A common point of failure in translation of preclinical neurological research to successful clinical trials comes in the giant leap from rodent models to humans. Non-human primates are phylogenetically close to humans, but cost and ethical considerations prohibit their widespread usage in preclinical trials. Swine have large, gyrencencephalic brains, which are biofidelic to human brains.

Predictive energetic tuning of C-Nucleophiles for the electrochemical capture of carbon dioxide.

This work maps the thermodynamics of electrochemically generated C-nucleophiles for reactive capture of CO. We identify a linear relationship between the pK, the reduction potential of a protonated nucleophile ( ), and the nucleophile's free energy of CO binding ( ). Through synergistic experiments and computations, this study establishes a three-parameter correlation described by the equation for a series of twelve imidazol(in)ium/N-heterocyclic carbene pairs with an of 0.