Publications by authors named "T Stiller"
Marriage promotes breastfeeding duration through economic and social supports. The COVID-19 pandemic disproportionately affected marginalized communities and impacted women's employment and interpersonal dynamics. This study examined how marital status affects breastfeeding duration across socioeconomic and racially minoritized groups during COVID-19, aiming to inform social support strategies for vulnerable families in public health crises.
View Article and Find Full Text PDFBackground: Marriage promotes breastfeeding duration through economic and social supports. The COVID-19 pandemic disproportionately affected marginalized communities and impacted women's employment and interpersonal dynamics. This study examined how marriage affects breastfeeding duration across socioeconomic and racially minoritized groups during COVID-19, aiming to inform social support strategies for vulnerable families in public health crises.
View Article and Find Full Text PDFDespite recent therapeutic advances, metastatic castration-resistant prostate cancer (mCRPC) remains lethal. Chimeric antigen receptor (CAR) T cell therapies have demonstrated durable remissions in hematological malignancies. We report results from a phase 1, first-in-human study of prostate stem cell antigen (PSCA)-directed CAR T cells in men with mCRPC.
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- Pediatric brain tumor prognosis is currently poor, but there is hope that CAR T cell therapy could improve outcomes, as indicated by a study involving the first six treated patients in a clinical trial (NCT04510051).
- Interim results show that three out of five evaluable patients experienced some temporary clinical benefits, while overall there were no serious side effects from the treatment, despite some patients experiencing common issues like cytopenias.
- Analysis of immune responses revealed interesting interactions between CAR T cells and the patient's immune system, highlighting differences in T cell populations in the cerebrospinal fluid compared to peripheral blood, suggesting the need for careful sampling in future studies.
The ligand-activated transcription factors Nur77, Nurr1, and NOR-1 forming the NR4A family of nuclear receptors are considered as potential targets in various pathologies, including neurodegeneration and cancer. However, chemical tools for pharmacological NR4A modulation as a prerequisite for target validation are rare. Recent findings suggest that NR4As bind fatty acid metabolites and fatty acid mimetic (FAM) drugs, opening new opportunities for NR4A modulator development.
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