Publications by authors named "T Stevens"
Background And Aims: Previous literature suggests that faecal calprotectin (FC) discriminates Crohn's disease perianal fistulas from cryptoglandular fistulas, irrespective of luminal disease. This study aims to prospectively validate this and analyse if increased local fistula calprotectin levels are associated with fistula characteristics.
Methods: In this prospective study, all consecutive patients with an active perianal fistula undergoing examination under anaesthesia were included.
Introduction And Importance: Leptomeningeal carcinomatosis (LC) is an uncommon but severe complication of advanced esophageal adenocarcinoma. Typically diagnosed through MRI and cerebrospinal fluid analysis, LC carries a poor prognosis despite aggressive management.
Case Presentation: A 64-year-old male with a history of coronary artery disease, diabetes, and other comorbidities presented with progressive dysphagia.
Optimal gene transcription is achieved through precise interactions between transcription factors and their DNA binding sites. We provide evidence that conserved distally located 5'-flanking sequences interact directly with the intrinsically disordered amino-terminal region of the thyroid receptor-α (TRα) to control transcriptional activity. Simulated modeling and dynamics with multiple ChIP-seq-derived sequences consistently reveal specific lysine/arginine-DNA minor groove interactions.
View Article and Find Full Text PDFChildren diagnosed with acute myeloid leukaemia (paediatric AML [pAML]) have limited treatment options and relapse rates due to chemoresistance and refractory disease are over 30%. Current treatment is cytotoxic and in itself has long-lasting harsh side effects. New, less toxic treatments are needed.
View Article and Find Full Text PDFArticle Synopsis
- Mitochondrial function relies on properly positioned membrane proteins in the outer mitochondrial membrane, which features around 150 proteins predominantly made up of α-helical transmembrane domains.
- The expansion of this family of proteins in metazoans is crucial for various processes like mitochondrial fusion, fission, and immune responses, highlighted by the role of MTCH2 as an important insertase.
- The text introduces three experimental methods to study α-helical protein insertion: a split fluorescent reporter system for live cell monitoring, an approach for isolating functional mitochondria for lab assays, and a technique for reconstituting protein insertion using proteoliposomes with MTCH2, paving the way for deeper analysis of mitochondrial protein dynamics.