Publications by authors named "T Stellato"

Autoantibody against phospholipase A2 receptor (anti-PLA2R) is a sensitive and specific biomarker of idiopathic membranous nephropathy (iMN), being found in approximately 70% of iMN patients and only occasionally in other glomerular diseases. However, whereas its diagnostic specificity vs. normal controls and other glomerulonephritides (GN) has been firmly established, its specificity vs.

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Autoantibodies to M-type phospholipase A2 receptor (PLA2R) are specific markers of idiopathic membranous nephropathy (IMN). They can differentiate IMN from other glomerular diseases and primary from secondary forms of MN. Preliminary data suggest that anti-PLA2R antibody titer correlates with disease activity but more solid evidence is needed.

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Article Synopsis
  • Retinal vasculopathy with cerebral leukodystrophy (RVCL) is a rare adult-onset disorder linked to specific mutations in the TREX1 gene, primarily affecting blood vessel health and leading to various systemic issues.
  • The case discussed involves a patient with RVCL exhibiting widespread complications, including brain calcifications, pseudotumors, retinopathy, and organ failures, identifying a novel TREX1 mutation.
  • The study underscores the complexity of diagnosing RVCL, highlighting the necessity to look for TREX1-related mutations in young adults with systemic microangiopathy involving multiple organs.
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It is well known that chronic hepatitis B plays a detrimental role on survival in patients on long-term dialysis and after kidney transplantation. The advent of nucleos(t)ide analogues offers the opportunity to change the natural history of hepatitis B in patients with chronic kidney disease. We report our experience on lamivudine use in two patients with HBV-related liver disease on long-term dialysis.

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Background: Only few cases of acute renal failure (ARF) requiring dialysis have been reported in patients with idiopathic nephrotic syndrome (NS). This study aims to better define the clinical outcome and treatment of this condition.

Methods: A pilot enquiry regarding the occurrence of ARF requiring dialysis in patients with NS and biopsy proven minimal changes (MC) or focal segmental glomerulosclerosis (FSGS) was conducted among 5 nephrology centers.

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