Publications by authors named "T Stankiewicz"
Obesity is a risk factor for increased lung damage and disease severity during influenza virus infection. White adipose tissue (WAT) inflammation is a key driver of disease pathogenesis in obesity. Whether and how obesity modifies lung and WAT immune cell character and function in obesity to amplify influenza disease severity remains unknown.
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- Vertical transmission of obesity plays a significant role in the ongoing obesity epidemic and related metabolic diseases, yet current models fail to accurately reflect human obesity.
- This study introduces a new mouse model that simulates "human-like" obesity by using a specific diet and housing conditions, revealing that maternal obesity negatively impacts neonatal survival, increases offspring fat accumulation, and heightens their risk for obesity-related diseases.
- The findings suggest that severe maternal obesity alters the offspring's microbiome and creates a harmful inflammatory environment during pregnancy, which is supported by similar patterns observed in a human birth cohort study.
Article Synopsis
- Influenza virus-induced pneumonia poses significant public health risks, with obesity, metabolic diseases, and female sex identified as independent factors worsening the disease.
- The lack of experimental models for studying severe obesity in female mice has limited research, but this study successfully induced severe obesity in female mice using a high-fat diet and thermoneutral housing.
- The findings reveal that while traditionally lean mice show similar responses to influenza, introducing severe obesity and metabolic disease in female mice results in disease severity comparable to that of obese males, highlighting the critical role of these factors in influenza severity.
The Janus Kinase 2 (JAK2) tyrosine kinase is an essential component of signal transduction of the class II cytokine receptors, including the growth hormone receptor. Therefore, it may play a crucial role in the signaling pathway of the somatotropic axis, which influences growth, development, and reproductive traits in ruminants. For this purpose, for three breeds of cattle (Hereford, Angus, and Limousin; a total of 781 individuals), two polymorphic sites located in exon 16 (rs210148032; p.
View Article and Find Full Text PDFClinical evidence points to a function for B cell-activating factor (BAFF) in pregnancy. However, direct roles for BAFF-axis members in pregnancy have not been examined. Here, via utility of genetically modified mice, we report that BAFF promotes inflammatory responsiveness and increases susceptibility to inflammation-induced preterm birth (PTB).
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