Differential diagnosis in immune checkpoint inhibitors neurotoxicity.

Background: Neurologic symptoms seen in patients receiving immune checkpoint inhibitors (ICI) may not be entirely caused by immunotoxicity. We aim to highlight these confounding conditions through clinical cases to encourage early recognition and management.

Methods: We describe a series of seven cases from our institution that were treated with ICI and presented with Neurologic symptoms and were diagnosed with superimposed conditions beyond immunotoxicity.

Prognostic, biological, and structural implications of FLT3-JMD point mutations in acute myeloid leukemia: an analysis of Alliance studies.

The FLT3 gene frequently undergoes mutations in acute myeloid leukemia (AML), with internal tandem duplications (ITD) and tyrosine kinase domain (TKD) point mutations (PMs) being most common. Recently, PMs and deletions in the FLT3 juxtamembrane domain (JMD) have been identified, but their biological and clinical significance remains poorly understood. We analyzed 1660 patients with de novo AML and found FLT3-JMD mutations, mostly PMs, in 2% of the patients.

Optimising detector readout settings for the detection of spatial correlations between SPDC photon-pairs.

SPDC photon-pairs exhibit spatial correlations which can be measured using detector arrays sensitive to single photons. However, these detector arrays have multiple readout modes and in order to optimise detection it is important to select the optimum mode to detect the correlations against a background of optical and electronic noise. These quantum correlations enable applications in imaging, sensing, communication, and optical processing.

Molecular Discovery of Filarial Nematode DNA in an Endangered Wild Pinniped (Galapagos Sea Lion, ).

Rapidly changing environments are contributing to the spread of non-native species and their associated pathogens into new and vulnerable ecosystems, such as the Galapagos archipelago. These pathogens represent a significant threat to emblematic species. The Galapagos sea lion () (GSL) is an endangered and endemic pinniped that is increasingly at risk of acquiring infectious diseases due to interactions with introduced companion animals.

A feature-based qualitative assessment of smoking cessation mobile applications.

Understanding users' acceptance of smoking cessation interventions features is a precursor to mobile cessation apps' uptake and use. We gauged perceptions of three features of smoking cessation mobile interventions (self-monitoring, tailored feedback and support, educational content) and their design in two smoking cessation apps, Quit Journey and QuitGuide, among young adults with low socioeconomic status (SES) who smoke. A convenience sample of 38 current cigarette smokers 18-29-years-old who wanted to quit and were non-college-educated nor currently enrolled in a four-year college participated in 12 semi-structured virtual focus group discussions on GoTo Meeting.