Publications by authors named "T Speck"
The shape of biological matter is central to cell function at different length scales and determines how cellular components recognize, interact and respond to one another. However, their shapes are often transient and hard to reprogramme. Here we construct a synthetic cell model composed of signal-responsive DNA nanorafts, biogenic pores and giant unilamellar vesicles (GUVs).
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- DNA is a powerful tool for creating synthetic nanostructures, and while single molecules can be engineered to fold into complex shapes, less is known about the behavior of larger DNA assemblies in solution.
- Recent research explores how single-stranded DNA fluids can separate into dense and dilute phases, which could lead to new types of hierarchical structures.
- A simplified model has been developed to understand single-polymer behavior and phase separation, but challenges remain in accurately simulating interactions, particularly the role of counterions in affecting electrostatic attractions.
Article Synopsis
- The study examined the effectiveness of using multiparametric MRI (mpMRI) as a diagnostic tool for identifying clinically significant prostate cancer (csPCa) and its impact on managing biopsy decisions in men suspected of having the disease.
- Conducted over three years at multiple urology practices in Berlin, the trial monitored participants with either positive or negative mpMRI results, allowing for a better understanding of patient outcomes and the safety of the protocol.
- Results indicated that a significant number of men avoided unnecessary biopsies over time, with a small percentage of those initially deemed negative later diagnosed with csPCa, suggesting the monitoring strategy may be feasible and safe for patients.
Article Synopsis
- The study explores the use of biobased cellulosic materials and bioinspired 4D-printing for creating adaptive shading systems in building facades to reduce carbon emissions and energy consumption.
- The key focuses include assessing the movement of 4D-printed bilayers in response to temperature and humidity, testing their effectiveness in varying weather conditions over a year, and implementing these systems in actual building facades for practical applications.
- Overall, the research highlights the potential of these innovative materials and techniques to provide eco-friendly, efficient solutions for managing indoor climates and addressing climate change.