Publications by authors named "T Spangenberg"
New antimalarial combination therapies with novel modes of action are required to counter the emergence and spread of drug resistance against existing therapeutics. Here, we present a study to evaluate the preventive activity of a combination of clinical antimalarial drug candidates, cabamiquine and ganaplacide, that have multistage activity against the liver and blood stages of infection. Cabamiquine (DDD107498, M5717) inhibits parasite protein synthesis, and ganaplacide (KAF156) inhibits protein trafficking, blocks the establishment of new permeation pathways, and causes endoplasmic reticulum expansion.
View Article and Find Full Text PDF[Severe intoxication after yew (Taxus) ingestion-case report and literature review].
Med Klin Intensivmed Notfmed
October 2024
Background: Severe yew (Taxus) intoxication is a rare condition that can lead to life-threatening cardiac arrhythmia. The survival of patients requires highly specialized emergency and intensive care treatment.
Objectives: Systematic overview of the clinical picture and important treatment options.
Article Synopsis
- The text discusses the design and performance of a high-transmission soft X-ray spectrometer located at the KIT Light Source's X-SPEC beamline.
- Key improvements include optimizing the spectrometer for better transmission by maximizing the solid angle and the efficiency of its gratings and CMOS detector, which has over 90% quantum efficiency for soft X-rays.
- The setup enables rapid collection of inelastic soft X-ray scattering maps in under a minute, with a wide energy range of 45 to 2000 eV, and high resolving power with only two gratings.
Article Synopsis
- Cryptosporidium parvum and C. hominis are dangerous parasites causing severe diarrhea, particularly in children and people with weakened immune systems, with limited treatment options available.
- Researchers screened 278 compounds and discovered that certain pyrazolopyrimidine human phosphodiesterase (PDE)-V inhibitors showed strong effectiveness against these parasites in infected mice, targeting their ability to exit host cells and demonstrating minimal side effects.
- The study identified CpPDE1 as a crucial target for these inhibitors, as mutations in this enzyme affect the efficiency of treatment, opening new avenues for developing more effective therapies against Cryptosporidium infections.
Article Synopsis
- The study investigates the effects of cabamiquine and pyronaridine on the P. falciparum malaria parasite, looking at their performance as standalone treatments and in combination therapy.
- Using field isolates and a pharmacometrics model, researchers create an interaction map to simulate effective clinical dose ratios for these antimalarials.
- Results indicate that while pyronaridine alone is less effective, the combination of cabamiquine and pyronaridine significantly improves parasite killing, suggesting the methodology can aid in developing new malaria treatments.