Publications by authors named "T Souza"
COVID-19 disease, triggered by SARS-CoV-2 virus infection, has led to more than 7.0 million deaths worldwide, with a significant fraction of recovered infected people reporting postviral symptoms. Smart surfaces functionalized with nanoparticles are a powerful tool to inactivate the virus and prevent the further spreading of the disease.
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- Runners who don't allow enough recovery time after training may be at a higher risk for injuries due to fatigue and altered movement patterns.
- A study looked at how different running intensities affect lower-limb joint movements and coordination during a single-leg squat in 30 healthy runners.
- Immediate and longer-term changes showed that coordination patterns became less adaptive (more regular) after moderate and high-intensity runs, but traditional kinematic analysis did not effectively capture these changes.
Coronavirus disease 2019 (COVID-19) still causes death in elderly and immunocompromised individuals, for whom the sustainability of the vaccine response may be limited. Antiviral treatments, such as remdesivir or molnupiravir, have demonstrated limited clinical efficacy. Nirmatrelvir, an acute respiratory syndrome coronavirus 2 (SARS-CoV-2) major protease inhibitor, is clinically effective but has been associated with viral rebound and antiviral resistance.
View Article and Find Full Text PDFA New Heteroleptic Zn(II) Complex with Schiff Bases Sensitizes Triple-Negative Breast Cancer Cells to Doxorubicin and Paclitaxel.
Pharmaceutics
December 2024
: Triple-negative breast cancer (TNBC) is the most challenging molecular subtype of breast cancer (BC) in clinical practice, associated with a worse prognosis due to limited treatment strategies and its insensitivity to conventional drugs. Zinc is an important trace element for homeostasis, and its Schiff base metal complexes have shown promise in treating advanced tumors. In this study, four new heteroleptic Zn(II) complexes (-) with Schiff bases were synthesized, characterized, and evaluated for their activity in BC cells.
View Article and Find Full Text PDFUnderstanding the growth patterns of genotypes optimizes their selection and management. The objective of this study is to investigate the seasonal variations in the morphology and biochemistry of clone leaves, considering climatic conditions and the maturation cycle. Morphological characteristics and carbohydrate contents of the leaves were analyzed throughout the growth cycle.
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