[Cervical leiomyosarcoma after uterine surpravaginal amputation].

The rare case of the cervical leiomyosarcoma in a patient with previous uterine amputation has been described. Clinical signs, risk groups and methods of treatment of sarcomas have been shortly discussed.

Tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in the placenta and myometrium.

Background: Placental abruption is mainly due to the rupture of the uterine spiral arteries, but adjacent tissues are also damaged and substances derived from disintegrated placenta and myometrium probably cause coagulation disturbances, such as hypofibrinogenemia and disseminated intravascular coagulation (DIC).

Aim: To measure whether placenta and myometrium are significant sources of tissue factor (TF) and tissue factor pathway inhibitor (TFPI), the components of key role in the initiation of coagulation.

Materials And Methods: Strips of placenta and myometrium were obtained from 48 women delivered by cesarean section at term.

[The clinical value of determination of fibronectin: the endothelium lesion marker in EPH-gestosis].

Plasma fibronectin concentration, AT III, PAI-1 and platelet count in 115 patients with gestosis, chronic hypertension and in physiological pregnancy were estimated. The obtained results indicate the significant fibronectin increase in gestosis patients. The positive correlation between fibronectin concentration and gestosis index was found.

Inhibition of murine melanoma cell-matrix adhesion and experimental metastasis by albolabrin, an RGD-containing peptide isolated from the venom of Trimeresurus albolabris.

Albolabrin, a 7.5-kDa cysteine-rich protein isolated from the venom of Trimeresurus albolabris, contains the arginine-glycine-aspartic acid (RGD) cell recognition sequence found in many cell adhesion-promoting extracellular matrix proteins, such as fibronectin and laminin. Albolabrin belongs to a family of RGD-containing peptides, termed disintegrins, recently isolated from the venom of various vipers and discovered to be potent inhibitors of both platelet aggregation and cell-substratum adhesion.

Identification of the disulfide bond pattern in albolabrin, an RGD-containing peptide from the venom of Trimeresurus albolabris: significance for the expression of platelet aggregation inhibitory activity.

Albolabrin is a 73 amino acid peptide isolated from the venom of Trimeresurus albolabris. It contains an RGD sequence and 12 cysteines and is a potent inhibitor of both platelet aggregation and fibrinogen binding to the GPIIb/IIIa complex. This protein shows a high degree of analogy (primarily due to the alignment of all cysteines and the RGD) with a number of other viper venom proteins which inhibit cell adhesion and platelet aggregation and are referred to as disintegrins: rhodostomin, trigramin, flavoridin, applagin, elegantin, and batroxostatin.