Validation of mitochondrial FMN as a predictor for early allograft dysfunction and patient survival measured during hypothermic oxygenated perfusion.

Hypothermic oxygenated machine perfusion (HOPE) preconditions liver grafts before transplantation. While beneficial effects on patient outcomes were demonstrated, biomarkers for viability assessment during HOPE are scarce and lack validation. This study aims to validate the predictive potential of perfusate flavin mononucleotide (FMN) during HOPE to enable the implementation of FMN-based assessment into clinical routine and to identify safe organ acceptance thresholds.

Debonding Characteristic and Survival Probability of Adhesive Flash-Free Ceramic Orthodontic Brackets Following pH Cycling.

Objectives:  Orthodontic bracket bond failure is an obstacle in clinical orthodontics. This study investigated the influence of pH cycling on the shear bond strength (SBS), adhesive remnant index (ARI), and survival probability of adhesive-precoated flash-free ceramic brackets.

Materials And Methods:  Forty mandibular premolars were randomly divided into two groups ( = 20): C: noncoated orthodontic brackets, and F: flash-free adhesive-precoated orthodontic brackets.

Lipopeptides from Bacillus atrophaeus MCM61 and melatonin suppress gray mold-induced oxidative stress in cut roses (Rosa hybrida L.) and improve vase life.

Application of melatonin and lipopeptides (LPs) derived from Bacillus strains is considered an efficient strategy to control plant diseases at both pre and postharvest stages. However, the combined application of melatonin and LPs has not been studied yet. Therefore, the present study presents the synergistic effect of melatonin and LPs produced by Bacillus atrophaeus strain MCM61 against gray mold disease and its impact on quality parameters and vase life of cut roses.

A one health roadmap towards understanding and mitigating emerging Fungal Antimicrobial Resistance: fAMR.

The emergence of fungal antimicrobial resistance-fAMR-is having a growing impact on human and animal health, and food security. This roadmap charts inter-related actions that will enhance our ability to mitigate the risk of fAMR. As humanity's reliance on antifungal chemicals escalates, our understanding of their one-health consequences needs to scale accordingly if we are to protect our ability to manage the global spectrum of fungal disease sustainably.

Dual hypothermic oxygenated machine perfusion of the liver reduces post transplant biliary complications - a retrospective cohort study.

Background: Corroborating evidence for use of hypothermic oxygenated machine perfusion (HOPE) prior to orthotopic liver transplantation (OLT) suggests a beneficial effect in regards to biliary complications. Here, we aim to evaluate whether perfusion via portal vein alone (sHOPE) or via additional perfusion of the hepatic artery (dHOPE) have diverging impact on outcomes after OLT when compared to use of static cold storage (SCS).

Methods: Consecutive patients undergoing OLT at Medical University of Vienna (2018 to 2023) were retrospectively analyzed.