Publications by authors named "T Sola Martinez"
The development of ribosome profiling (Ribo-seq) by Ingolia et al. introduced a powerful new method for monitoring translation genome-wide. Application of Ribo-seq across multiple organisms has since revealed thousands of unannotated translated small open reading frames (ORFs) and enhanced efforts to study their encoded proteins, called microproteins.
View Article and Find Full Text PDFBackground: To reduce the number of deaths caused by exsanguination, the initial management of severe trauma aims to prevent, if not limit, the lethal triad, which consists of acidosis, coagulopathy, and hypothermia. Recently, several studies have suggested adding hypocalcemia to the lethal triad to form the lethal diamond, but the evidence supporting this change is limited. Therefore, the aim of this study was to compare the lethal triad and lethal diamond for their respective associations with 24-h mortality in severe trauma patients receiving transfusion.
View Article and Find Full Text PDFA computational tool to optimize clinical trial parameter selection in Duchenne muscular dystrophy: A practical guide and case studies.
CPT Pharmacometrics Syst Pharmacol
November 2024
Article Synopsis
- * A new clinical trial simulator (CTS) has been developed using five models that track changes in functional test performances, offering a way to optimize trial parameters and endpoints for DMD studies.
- * This report illustrates the CTS’s functionality through two case studies, showcasing how it can enhance trial design while maintaining statistical significance, ultimately preventing unnecessary increases in trial size and duration.
Article Synopsis
- - The study aimed to determine if severe traumatic rhabdomyolysis (with CK levels > 5000 U/L) affects the likelihood of death within 30 days for trauma patients, utilizing a causal inference approach in a multicenter cohort in France.
- - An analysis of 8592 patients revealed that 18% had severe RM, primarily affecting young males with blunt trauma, yet it did not significantly impact overall 30-day mortality rates despite associated complications.
- - While patients with severe RM had higher rates of multiorgan failure and septic shock during ICU stays, this risk was not a significant predictor of death when adjusted for confounding factors.