Publications by authors named "T Sloan"
Peatland drainage is a large source of anthropogenic CO emissions. While conversion to agriculture is widely acknowledged to lead to "irrecoverable" carbon (C) losses, in contrast the C impacts of peatland forestry are poorly understood, especially in intensively managed plantations. Losses of C from peat oxidation are highly variable and can be compensated for by gains of C in trees, depending on the lifecycle of the timber and timescale considered.
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- Advances in imaging techniques have resulted in the production of large microscopy datasets, necessitating new tools for data analysis.
- 'Cell PLasticity Analysis Tool' (cellPLATO) is a Python software developed for analyzing and classifying cell behaviors by examining cell morphology and movement over time.
- Using cellPLATO, researchers uncovered eight distinct behavioral subsets and four migration trajectories of natural killer (NK) cells influenced by IL-15, demonstrating that it enhances migratory plasticity in response to different integrin ligands.
Skeletal remains of sauropod dinosaurs have been known from Australia for over 100 years. Unfortunately, the classification of the majority of these specimens to species level has historically been impeded by their incompleteness. This has begun to change in the last 15 years, primarily through the discovery and description of several partial skeletons from the Cenomanian-lower Turonian (lower Upper Cretaceous) Winton Formation in central Queensland, with four species erected to date: , , , and .
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- Natural killer (NK) cells are key immune cells that target and destroy infected or cancerous cells, identified by the presence of the CD56 protein.
- CD56 is crucial for NK cell migration on specific surfaces (like ICAM-1) and helps maintain cell directionality and actin flow during movement.
- The study shows that the intracellular part of CD56 (NCAM-140) is essential for its function, affecting actin dynamics and integrin turnover, which are important for efficient NK cell movement.
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- NK cells are essential for targeting and eliminating virally infected and cancerous cells, identified mainly by the presence of CD56.
- CD56's functions in NK cells include aiding in their movement and cytotoxic capabilities, although it remains under-researched.
- Recent findings reveal that CD56 is crucial for NK cell migration on ICAM-1, maintaining cell polarity, and regulating actin dynamics, with its intracellular domain playing a significant role in these processes.