Structure-function relationship of phase-separated liposomes containing diacylglycerol analogues.

The composition and morphology of lipid-based nanoparticles can influence their overall behavior. Previously, we demonstrated that phase separation in liposomes composed of DSPC and a diacylglycerol lipid analogue (DOaG) drives the biodistribution towards a specific subset of endothelial cells in zebrafish embryos. In the absence of traditional targeting functionalities (, antibodies, ligands), this selectivity is mediated solely by the unique liposome morphology and composition, characterized by a DOaG-rich lipid droplet within the DSPC-rich phospholipid bilayer.

Crystal structure of bis-{3-(3,4-di-meth-oxy-phen-yl)-5-[6-(pyrazol-1-yl)pyridin-2-yl]-1,2,4-triazol-3-ato}iron(II)-methanol-chloro-form (1/2/2).

The unit cell of the title compound, [Fe(CHNO)]·2CHOH·2CHCl, consists of a charge-neutral complex mol-ecule, two methanol and two chloro-form mol-ecules. In the complex, the two tridentate 2-(5-(3,4-di-meth-oxy-phen-yl)-1,2,4-triazol-3-yl)-6-(pyrazol-1-yl)pyridine ligands coordinate to the central Fe ion through the N atoms of the pyrazole, pyridine and triazole groups, forming a pseudo-octa-hedral coordination sphere. Neighbouring tapered mol-ecules are linked through weak C-H(pz)⋯π(ph) inter-actions into one-dimensional chains, which are joined into two-dimensional layers through weak C-H⋯N/C/O inter-actions.

Crystal structure of caesium dimethyl--benzoyl-amido-phosphate monohydrate.

The caesium salt of dimethyl--benzoyl-amido-phosphate, namely, aqua-[di-meth-yl (-benzoyl-amido-κ)phospho-nato-κ]caesium, [Cs(CHNOP)(HO)] or Cs·HO, is reported. The compound crystallizes in the monoclinic crystal system in the 2/ space group and forms a mono-periodic polymeric structure due to the bridging function of the dimethyl--benzoyl-amido-phosphate anions towards the caesium cations.

Crystal structure of bis-{3-(3,4-di-methyl-phen-yl)-5-[6-(1-pyrazol-1-yl)pyridin-2-yl]-4-1,2,4-triazol-4-ido}iron(II) methanol disolvate.

As a result of the high symmetry of the 2 structure, the asymmetric unit of the title compound, [Fe(CHN)]·2MeOH, consists of half of a charge-neutral complex mol-ecule and a discrete methanol mol-ecule. The planar anionic tridentate ligand 2-[5-(3,4-di-methyl-phen-yl)-4-1,2,4-triazol-3-ato]-6-(1-pyrazol-1-yl)pyridine coordinates the Fe ion meridionally through the N atoms of the pyrazole, pyridine and triazole groups, forming a pseudo-octa-hedral coordination sphere of the central ion. The average Fe-N bond distance is 1.

Crystal structure of bis-{3-(3-bromo-4-methoxyphenyl)-5-[6-(1-pyrazol-1-yl)pyridin-2-yl]-1,2,4-triazol-3-ato}-iron(II) methano-l disolvate.

The unit cell of the title compound, [Fe(CHBrNO)]·2MeOH, consists of a charge-neutral complex mol-ecule and two independent mol-ecules of methanol. In the complex mol-ecule, the two tridentate ligand mol-ecules 2-[5-(3-bromo-4-meth-oxy-phen-yl)-4-1,2,4-triazol-3-yl]-6-(1-pyrazol-1-yl)pyridine coordinate to the Fe ion through the N atoms of the pyrazole, pyridine and triazole groups, forming a pseudo-octa-hedral coordination sphere around the central ion. In the crystal, neighbouring asymmetric mol-ecules are linked through weak C-H(pz)⋯π(ph) inter-actions into chains, which are then linked into layers by weak C-H⋯N/C inter-actions.