Publications by authors named "T Shiroyama"
Article Synopsis
- Overcoming resistance to osimertinib, an important drug for lung cancer, hinges on understanding the role of EV-derived microRNAs (EV-miRNAs) in treatment outcomes.
- Researchers found that the microRNA miR-130a-3p was upregulated in EVs from osimertinib-resistant lung adenocarcinoma cells, promoting cell survival against the drug.
- Lower levels of serum miR-130a-3p in patients were linked to better treatment progression, suggesting it could be a valuable biomarker and therapeutic target for managing osimertinib resistance.
Data for herbicide effects on plant flowering are needed to determine potential impacts on plant reproduction. Thus, flowering phenology was determined for up to 12 weeks after herbicide treatment for native Willamette Valley plants growing in small plots on two Oregon State University experimental farms. Six perennial species were evaluated: Camassia leichtlinii (CALE), Elymus glaucus (ELGL), Eriophyllum lanatum (ERLA), Festuca idahoensis subsp.
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- CAR T cell therapy has shown success in treating blood cancers but struggles with solid tumors like non-small cell lung cancer (NSCLC) due to a lack of specific cell surface targets.
- Researchers identified that CD98 heavy chain protein is overexpressed in NSCLC cells and could serve as a target for CAR T cells.
- A specific monoclonal antibody called R8H283, which reacts selectively with NSCLC cells without impacting normal tissues, led to the development of CAR T cells that demonstrated significant anti-tumor effects in model studies.
Background: Chemoimmunotherapy is a standard treatment for advanced non-small-cell lung cancer (NSCLC). However, data on clinical predictive factors remain scarce.
Objective: We aim to identify clinical biomarkers in patients undergoing chemoimmunotherapy.