Publications by authors named "T Shioiri"

Purpose: Investigating the status and challenges associated with radiological technologists acting as assistants during angiography and interventional radiology (IVR) through task shift/share.

Methods: The survey period was from August 1, 2023 to September 30, 2023. A 10-item questionnaire survey was conducted nationwide, targeting 676 hospitals equipped with angiography facilities.

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  • - The study investigates the link between rare copy number variations (CNVs) in synaptic genes and bipolar disorder (BD) in a Japanese population, using genome hybridization techniques on nearly 2,000 BD patients and 2,760 controls.
  • - Results indicate a strong association between the RNF216 gene and BD, with significant findings also related to postsynaptic membrane components, suggesting these genetic factors contribute to BD risk.
  • - The findings enhance understanding of BD's genetic underpinnings, highlighting the importance of CNVs in gene regions that may influence the disorder's development.
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Leptin, a hormone mainly secreted by adipocytes, has attracted significant attention since its discovery in 1994. Initially known for its role in appetite suppression and energy regulation, leptin is now recognized for its influence on various physiological processes, including immune response, bone formation, and reproduction. It exerts its effects by binding to receptors and initiating an intracellular signaling cascade.

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  • The study explores how dietary habits may influence the prevention and management of schizophrenia (SCZ) and bipolar disorder (BD) in older adults, particularly in relation to genetic predispositions and lifestyle-related diseases.
  • A cohort of 730 older patients was assessed for their dietary habits across various food categories while calculating polygenic risk scores (PRSs) for SCZ and BD based on large-scale genetic studies.
  • Findings indicated that higher genetic risk for SCZ and BD is correlated with lower consumption of nutrient-rich foods like light-colored vegetables and soybeans, with notable differences in dietary impacts between types of BD, especially BD I.
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  • * Patients with schizophrenia or delusional disorder, especially older women, are at a higher risk for developing Alzheimer's, while a significant percentage of Alzheimer's patients experience psychotic symptoms that can worsen their condition.
  • * The review highlights weak genetic correlations between schizophrenia and Alzheimer's, pointing out inconsistencies in polygenic risk scores, and underscores the need for further research into their genetic links and impacts on treatment and prevention strategies.
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