Publications by authors named "T Shiohara"
Article Synopsis
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe, rare skin reactions primarily triggered by drugs, leading to significant health risks and complications.
- The review suggests new diagnostic criteria to better identify these conditions and highlights recent research on how specific immune responses and genetic factors contribute to their development.
- It also discusses current and emerging treatment options, including debates on immunosuppressive therapies and new drug developments targeting specific mechanisms involved in SJS/TEN, advocating for a more collaborative approach in medical research to improve patient care.
Article Synopsis
- The study aimed to analyze the occurrence and factors influencing eye issues in patients with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in Japan from 2016 to 2018, comparing these results with a previous survey from 2005-2007.
- A total of 240 cases were examined, revealing a significant decrease in ocular complications from 39.2% to 14.0%, credited to improved treatment timing and methods.
- Key finding indicates that early diagnosis and treatment have led to better eye health outcomes for SJS/TEN patients, particularly with enhanced systemic treatments and corticosteroid usage compared to earlier years.*
Importance: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but potentially fatal drug hypersensitivity reaction. To our knowledge, there is no international consensus on its severity assessment and treatment.
Objective: To reach an international, Delphi-based multinational expert consensus on the diagnostic workup, severity assessment, and treatment of patients with DRESS.
Article Synopsis
- A study developed a Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) severity (DDS) score to predict complications associated with drug-induced hypersensitivity syndrome (DIHS), particularly looking at severe complications like myocarditis and autoimmune diseases.
- A retrospective analysis of 48 patients in Japan identified that a higher DDS score (≥4.0) could indicate a higher risk for these complications, while no complications were seen in those with lower scores (≤2.0).
- Findings suggested that the use of corticosteroids may increase the risk of certain complications and deaths, particularly in patients with infectious diseases, while early treatment for cytomegalovirus seemed to prevent complications.