Publications by authors named "T Shintani"

Metastasis in patients with oral squamous cell carcinoma has been associated with a poor prognosis. However, sensitive and reliable tests for monitoring their occurrence are unavailable, with the exception of PET-CT. Circulating tumor cells and cell-free DNA have emerged as promising biomarkers for determining treatment efficacy and as prognostic predictors in solid tumors such as breast cancer and colorectal cancer.

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Article Synopsis
  • Overcoming resistance to osimertinib, an important drug for lung cancer, hinges on understanding the role of EV-derived microRNAs (EV-miRNAs) in treatment outcomes.
  • Researchers found that the microRNA miR-130a-3p was upregulated in EVs from osimertinib-resistant lung adenocarcinoma cells, promoting cell survival against the drug.
  • Lower levels of serum miR-130a-3p in patients were linked to better treatment progression, suggesting it could be a valuable biomarker and therapeutic target for managing osimertinib resistance.
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Objectives: Claudin (CLD), a major component of tight junctions, is a four-transmembrane protein, and 24 subtypes have been reported in humans. CLD expression is highly tissue-specific; CLD1 has been reported to be expressed in the skin and mucosa. There have been few reports on CLD1 expression and its function in oral cancer.

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Background: This study was conducted to evaluate the differences between pre- and postoperative access conditions in percutaneous endovascular aortic repair (PEVAR).

Methods: Between December 2021 and October 2023, PEVAR was performed on 61 patients using the Perclose ProStyle (Abbott Vascular). Enhanced computed tomography and ankle-brachial index tests were performed preoperatively and postoperatively.

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Age-related physical and cognitive decline may be ameliorated by consuming functional foods. d-Allose, reported to have multiple health benefits, may temper aging phenotypes, particularly brain function. We investigated whether d-allose supplementation improves cognitive function.

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