Publications by authors named "T Shinomura"

The green alga Pediastrum duplex forms colonies through asexual reproduction and has a unique life cycle. To elucidate the mechanisms that regulate the asexual reproductive cycle in P. duplex, we analyzed the effects of light on the processes and gene expression involved in each step of the asexual reproductive cycle, revealing light irradiation to be essential for increasing the number of colonies.

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Photosynthetic organisms biosynthesize various carotenoids, a group of light-absorbing isoprenoid pigments that have key functions in photosynthesis, photoprotection, and phototaxis. Microalgae, in particular, contain diverse carotenoids and carotenoid biosynthetic pathways as a consequence of the various endosymbiotic events in their evolutionary history. Carotenoids such as astaxanthin, diadinoxanthin, and fucoxanthin are unique to algae.

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Light-independent functions of carotenoids in photosynthetic organisms are poorly understood. Here, we investigated the growth properties of microalga, Euglena gracilis, under altered light and temperature using norflurazon-treated carotenoid-deficient cells and genetically modified strains, including nonphotosynthetic SM-ZK and colorless cl4. Norflurazon treatment decreased carotenoid and chlorophyll contents, causing cell bleaching.

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Article Synopsis
  • * Ipriflavone was identified as a potential drug, restoring staining of cartilage cells and increasing extracellular matrix formation in a dose-dependent manner.
  • * In both cell experiments and mouse models of arthritis, Ipriflavone improved symptoms and decreased hyaluronan levels, suggesting it may be an effective treatment for inflammatory arthritis.
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Objective: Few studies have reported on the impact of oxidative stress on the dental implant failure. The aim of this study was to investigate the impact of hyperglycemia-induced oxidative stress on dental implant osseointegration in diabetes mellitus (DM).

Methods: Acid-treated titanium implants were bilaterally placed in the maxillary alveolar ridge of streptozotocin-induced diabetic (DM group) and control rats after extraction of first molars.

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