Likelihood ratios for fetal trisomy 21 based on nasal bone length in the second trimester: how best to define hypoplasia?

Objective: To determine the best measure of fetal nasal bone hypoplasia for trisomy 21 risk assessment in the second trimester.

Methods: This was a prospective, observational study performed at a single institution between February 2003 and December 2005. Fetuses with nasal bone length recorded sonographically between 16 and 20.

Assisted reproductive technology and pregnancy outcome.

Objective: To determine whether the use of assisted reproductive technology (ART) is associated with an increase in chromosomal abnormalities, fetal malformations, or adverse pregnancy outcomes.

Methods: A prospective database from a large multicenter investigation of singleton pregnancies, the First And Second Trimester Evaluation of Risk trial, was examined. Subjects were divided into 3 groups: no ART use, use of ovulation induction (with or without intrauterine insemination), and use of in vitro fertilization (IVF).

Radiofrequency ablation in a monochorionic twin discordant for fetal anomalies.

Radiofrequency ablation is a minimally invasive technique that has been used in selective reduction of acardiac twins. We report a case in which radiofrequency ablation was used to selectively reduce a monochorionic twin discordant for an abnormality.

Studies of transferrin recycling reconstituted in streptolysin O permeabilized Chinese hamster ovary cells.

Efficient transferrin receptor recycling is reconstituted when donor cytosol and ATP are added to the streptolysin O permeabilized cells. The rate of reconstituted recycling is dependent on the concentration of donor cytosol. The cytosol provides a factor(s) required for the transport of transferrin from the pericentriolar recycling compartment to the plasma membrane.