Clinical and demographic profiling of snakebite envenomation in a tertiary care centre in northern India.

Background: Snake bites are a major cause of emergency visits in tropical countries like India, with actual mortality and morbidity likely higher due to underreporting. The aim of the study was to analyze the clinical and demographic profiles of snake bites at the Department of Emergency Medicine, AIIMS Rishikesh, over two years (July 2021 to July 2023).

Methods: Patients aged over 18 with witnessed or suspected snake bites were included.

Peroxisome proliferator-activated receptor gamma ( )-mediated myocardial salvage in acute myocardial infarction managed with left ventricular unloading and coronary reperfusion.

Ischemic heart disease and acute myocardial infarction (AMI) is a leading cause of morbidity and mortality. Improvements have been made in coronary interventions to restore blood flow, but ischemia/reperfusion (I/R) injury significantly impacts clinical outcomes. We previously reported that activation of percutaneous mechanical unloading of the left ventricle (LV) with a transvalvular axial-flow device simultaneously with reperfusion improves myocardial salvage.

The Left Ventricular Outflow Tract Velocity Time Integral as a Predictor of Fluid Responsiveness in Patients With Sepsis-Related Acute Circulatory Failure.

Background: Sepsis is a major contributor to global morbidity and mortality. Effective fluid resuscitation is essential for managing septic shock, but it must be carefully monitored to avoid fluid overload and related complications. Recent studies have demonstrated that both inadequate and excessive fluid resuscitation are linked to poor outcomes.

Russell's viper bite induced cortical sinus thrombosis and diffuse alveolar haemorrhage.

Snakebites are critical medical emergencies that significantly contribute to emergency department visits during monsoon seasons. This case report details a patient who experienced simultaneous arterial and venous thrombosis of major intracranial vessels due to venom-induced consumptive coagulopathy. Additionally, the patient developed diffuse alveolar haemorrhage (DAH), highlighting the severe impact of these uncommon complications on prognosis.

A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease.

Background: Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate of ≈0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial.