Publications by authors named "T Shaipanich"
Article Synopsis
- - A study created a detailed map of the airway cells in patients with pulmonary long COVID, focusing on those who have persistent respiratory symptoms after a COVID-19 infection.
- - Participants with long COVID were compared to those whose symptoms had resolved or who had never been infected, with analysis revealing unique neutrophil clusters in the long COVID group.
- - The findings suggest that increased inflammation and changes in airway cell function, particularly involving neutrophils, may be responsible for the lingering respiratory issues seen in long COVID patients.
Bronchial Rheoplasty for Chronic Bronchitis: Results from a Canadian Feasibility Study with RheOx.
Int J Chron Obstruct Pulmon Dis
July 2024
Purpose: Chronic bronchitis (CB), a chronic obstructive pulmonary disease (COPD) phenotype defined by persistent mucus hypersecretion and cough, is associated with poor quality of life, exacerbations, and lung function impairment. Bronchial Rheoplasty (BR) delivers non-thermal pulsed electric fields to airway epithelium and submucosa. Preliminary studies demonstrated reduced airway goblet cell hyperplasia and symptom improvement in response to BR.
View Article and Find Full Text PDFBackground: DNA methylation may be a link between HIV, aging, and the increased risk of lung comorbidities. We investigated whether bronchoalveolar lavage (BAL) cells of people living with HIV (PLWH) demonstrate epigenetic disruptions and advanced epigenetic aging.
Methods: BAL cell DNA methylation from 25 PLWH and 16 HIV-uninfected individuals were tested for differential methylation of Alu and LINE-1 sites, markers of aging.
Single-cell RNA sequencing (scRNA-seq) is an important tool for understanding disease pathophysiology, including airway diseases. Currently, the majority of scRNA-seq studies in airway diseases have used invasive methods (airway biopsy, surgical resection), which carry inherent risks and thus present a major limitation to scRNA-seq investigation of airway pathobiology. Bronchial brushing, where the airway mucosa is sampled using a cytological brush, is a viable, less invasive method of obtaining airway cells for scRNA-seq.
View Article and Find Full Text PDFBackground: People living with HIV (PLWH) are at increased risk of developing Chronic Obstructive Pulmonary Disease (COPD) independent of cigarette smoking. We hypothesized that dysbiosis in PLWH is associated with epigenetic and transcriptomic disruptions in the airway epithelium.
Methods: Airway epithelial brushings were collected from 18 COPD + HIV + , 16 COPD - HIV + , 22 COPD + HIV - and 20 COPD - HIV - subjects.