Publications by authors named "T Semba"
Article Synopsis
- Triple-negative inflammatory breast cancer (TN-IBC) is the most aggressive form of breast cancer, and its specific genetic and immune characteristics are not well understood.
- This study conducted extensive genomic analyses of TN-IBC tumors from a phase II clinical trial, comparing them to stage III triple-negative non-inflammatory breast cancer (TN-non-IBC) samples.
- Key findings revealed that TN-IBC tumors have unique features, such as a lower mutation load and the presence of immune components that may hinder chemotherapy response, indicating a need for further research to identify potential biomarkers and treatment targets.
Background: Esophageal cancer is one of the most common types of cancer in Japan. Herein, we report the efficacy and safety of E7389-LF plus the immune checkpoint inhibitor, nivolumab, from the esophageal cancer cohort of the phase 2 part of Study 120.
Methods: Eligible patients received E7389-LF 2.
Tumours are composed of tumour cells and the surrounding tumour microenvironment (TME), and the molecular characterisation of the various elements of the TME and their interactions is essential for elucidating the mechanisms of tumour progression and developing better therapeutic strategies. Multiplex imaging is a technique that can quantify the expression of multiple protein markers on the same tissue section while maintaining spatial positioning, and this method has been rapidly developed in cancer research in recent years. Many multiplex imaging technologies and spatial analysis methods are emerging, and the elucidation of their principles and features is essential.
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- A global study has investigated the use of human pluripotent stem cell-derived retinal pigment epithelial cells (hiPSC-RPE) for treating diseases like age-related macular degeneration, highlighting the pros and cons of cell suspensions and sheets.
- The hiPSC-RPE strips were created to offer a less invasive method for cell delivery, demonstrating stable survival in a cynomolgus monkey model after transplantation into both damaged and healthy retinal areas.
- The transplanted RPE cells not only expanded more at the injury site without causing tumors but also exhibited important cellular characteristics for effective retinal therapy.
Diffuse-type gastric cancer (DGC) is a subtype of gastric cancer that is prone to peritoneal dissemination, with poor patient prognosis. Although intercellular adhesion loss between cancer cells is a major characteristic of DGCs, the mechanism underlying the alteration in cell-to-extracellular matrix (ECM) adhesion is unclear. We investigated how DGCs progress and cause peritoneal dissemination through interactions between DGC cells and the tumour microenvironment (TME).
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