Publications by authors named "T Sekita"
Dedifferentiated liposarcoma (DDLPS) comprises a high-grade dedifferentiated (DD) component and a juxtaposed well-differentiated (WD) component. The DD component is believed to originate from the WD component by acquiring additional genomic alterations. In this study, we performed multiregion genome, epigenome, and transcriptome analyses of three patients with DDLPS.
View Article and Find Full Text PDFPurpose: To re-evaluate images recovered from JCOG0911, a randomized phase 2 trial for newly diagnosed glioblastoma (nGBM) conducted by the Japan Clinical Oncology Group (JCOG) Brain Tumor Study Group.
Methods: The correlation between tumor volumes and survival was evaluated, followed by progression-free survival (PFS) analysis by independent central review based on Response Assessment in Neuro-Oncology (RANO) criteria using MRI recovered from 118 nGBM patients enrolled in the JCOG0911 trial. A radiomic analysis was also performed to identify radiomic features predictive of nGBM prognosis.
Article Synopsis
- * It aims to determine if having surgery followed by three courses of adjuvant chemotherapy is as effective as the standard approach of chemotherapy followed by surgery and then more chemotherapy.
- * The trial is a large, randomized phase III study that began in November 2022 and seeks to confirm that the new treatment method is not inferior regarding overall survival rates.
Article Synopsis
- * The study is a phase III trial testing whether high-dose therapy with autologous stem cell transplantation improves progression-free survival over simply observing patients who have responded well to initial treatment.
- * A total of 140 patients will participate from 52 hospitals in Japan over a period of 5.5 years, and the trial is officially registered in the Japan Registry of Clinical Trials.
Article Synopsis
- This study analyzes the long-term postoperative outcomes of limb-sparing surgery in children with knee-borne bone sarcoma, focusing on complications and functional results post-surgery.
- The review included 40 patients under 14 years old and assessed factors like complications, reconstruction success rates, and leg-length discrepancies over a minimum of five years.
- Key findings indicate that younger age and complications negatively affect functional outcomes, with leg-length discrepancies worsening performance, especially in younger patients.*