Publications by authors named "T Sekar"
Both innate and adaptive immunity are important components of the human defense system against various diseases including cancer. Human beta defensin-1 (hBD-1) is one such immunomodulatory peptide which is lost in malignant cancers, while high levels of expression are maintained in benign cells, making it a potential biomarker for the onset and metastasis of the disease. Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer for which no targeted therapy has been approved so far.
View Article and Find Full Text PDFAim: To evaluate the impact of a new, less-invasive micro-computed tomography (CT) service on autopsy service provision. We recorded parental consent, type of autopsy performed, autopsy reporting times and time taken for the body to be released from the mortuary.
Materials And Methods: A retrospective, single-centre case series was conducted for all perinatal deaths since the introduction of our micro-CT service in 2016, with a detailed review of records extracted from 2019 and 2021.
Article Synopsis
- Fibrosis is the abnormal buildup of connective tissue due to improper healing from injuries like lack of oxygen, infections, or trauma, affecting any organ and leading to dysfunction and failure.
- It also plays a significant role in cancer development, making early diagnosis and monitoring vital for improving patient outcomes.
- This paper specifically examines fibrosis in the genito-urinary system, highlighting current imaging technologies for detection and suggesting possible future research directions.
Article Synopsis
- Fibrosis is an abnormal buildup of connective tissue due to prolonged injuries like low oxygen, infections, or physical damage, which can lead to organ dysfunction and failure.
- It is also linked to cancer development and progression, making early diagnosis and monitoring crucial for treatment and improving patient outcomes.
- The text highlights the need for better understanding and application of advanced imaging techniques to detect fibrosis in abdominal organs, discussing both current technologies and future developments for early diagnosis.
Article Synopsis
- - Injury from factors like low oxygen, infections, or physical damage can disrupt normal tissue repair, leading to fibrosis, which affects organ function and can cause organ failure.
- - Fibrosis plays a significant role in cancer development and progression, making early diagnosis and ongoing monitoring crucial for managing diseases and improving patients' quality of life.
- - This work aims to review current imaging technologies used to detect fibrosis in thoracic organs and discuss future advancements in these imaging methods.