Publications by authors named "T Seijas Rosales"
The inherent antigen cross-reactivity of the T cell receptor (TCR) is balanced by high specificity. Surprisingly, TCR specificity often manifests in ways not easily interpreted from static structures. Here we show that TCR discrimination between an HLA-A*03:01 (HLA-A3)-restricted public neoantigen and its wild-type (WT) counterpart emerges from distinct motions within the HLA-A3 peptide binding groove that vary with the identity of the peptide's first primary anchor.
View Article and Find Full Text PDFαβ T cell receptor (TCR) recognition of peptide-MHC complexes lies at the core of adaptive immunity, balancing specificity and cross-reactivity to facilitate effective antigen discrimination. Early structural studies established basic frameworks helpful for understanding and contextualizing TCR recognition and features such as peptide specificity and MHC restriction. However, the growing TCR structural database and studies launched from structural work continue to reveal exceptions to common assumptions and simplifications derived from earlier work.
View Article and Find Full Text PDFGlutaminase controls the first step in glutaminolysis, impacting bioenergetics, biosynthesis and oxidative stress. Two isoenzymes exist in humans, GLS and GLS2. GLS is considered prooncogenic and overexpressed in many tumours, while GLS2 may act as prooncogenic or as a tumour suppressor.
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- Sepsis and septic shock are critical health issues linked to high mortality rates, with the inflammatory response playing a major role in organ dysfunction, particularly affecting the cardiovascular system through severe hypotension.* -
- Nitric oxide (NO) is a pivotal factor in both inflammation and cardiovascular issues during sepsis, influencing proteins through post-translational modifications, and DTNB is utilized to study these interactions by targeting reactive thiol groups in proteins.* -
- In experiments with sepsis-induced mice, DTNB treatment reduced lung vascular leakage, lowered nitrite/nitrate levels, and diminished inflammatory markers like IL-1ß, suggesting its potential benefits in managing sepsis-induced inflammation.*
Article Synopsis
- * The study developed a method for radiolabeling anthocyanins and nanoencapsulating them using citrus pectin and lysozyme, resulting in structures that are 190 nm in size and have a consistent spherical shape.
- * Findings showed that nanoencapsulated anthocyanins are absorbed more effectively than free anthocyanins in mice, with improved delivery to various organs, which may enhance their biological effects and potential medical applications.