Publications by authors named "T Seenappa"
Article Synopsis
- The study aims to identify risk factors that lead to unfavorable treatment outcomes for tuberculosis (TB) patients in India, in order to create a better care model for at-risk individuals.
- Conducted as part of a USAID-THALI project in Karnataka and Telangana, the research involved Community Health Workers assessing TB patients for potential risks and following their treatment outcomes.
- Results showed that patients with one or more risk factors—such as being male, having low education, being underweight, having HIV, and previous treatment history—were significantly more likely to experience death or unfavorable outcomes compared to those with no risks.
Alkaptonuria, a metabolic disorder characterized by a triad of homogentisic aciduria, arthritis and ochronosis is one of the first conditions in the charter of group of inborn errors of metabolism proposed to have Mendelian recessive inheritance. It is due to the deficiency of the enzyme homogentisic acid oxidase which catalyzes the conversion of homogentisic acid to maleylacetoacetic acid in the catabolism of tyrosine. Homogentisic acid thus accumulates in cells and body fluids and its oxidized polymers bind to collagen, leading to progressive deposition of grey to bluish black pigment resulting in degenerative changes in cartilage, intervertebral disc and other connective tissues, leading to arthritis which is the only disabling effect in an affected older individual.
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