Publications by authors named "T Sedlackova"
As the COVID-19 transits to endemicity, the frequency of clinical testing and its utility for determining lineage prevalence has declined. This situation is not unique to Slovakia but reflects a global trend, as attention shifts from COVID-19 to other post-pandemic issues and emerging global health challenges. Nevertheless, the pandemic itself has spurred advancements in monitoring the epidemiological situation.
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- Malignant melanoma (MM) has numerous genetic changes and a quick spread, making it important to find new plasma biomarkers for easier diagnosis and monitoring.
- The study investigated copy number variations (CNVs) in CDK genes and other specific genes through various genetic analyses, but found that CDK genes were not significant as biomarkers in plasma samples of MM patients compared to healthy individuals.
- Despite the lack of significance for CDK genes, the analysis did identify common CNV regions in the genome, suggesting that the gene DIP2C could be promising for further research in liquid biopsy applications.
Uropathogenic Escherichia coli (UPEC) is the most common causative agent of urinary tract infections, and strains that are resistant to antibiotics are a major problem in treating these infections. Phage therapy is a promising alternative approach that can be used to treat infections caused by polyresistant bacterial strains. In the present study, 16 bacteriophages isolated from sewage and surface water were investigated.
View Article and Find Full Text PDFBackground: COVID-19 caused by the SARS-CoV-2 infection may result in various disease symptoms and severity, ranging from asymptomatic, through mildly symptomatic, up to very severe and even fatal cases. Although environmental, clinical, and social factors play important roles in both susceptibility to the SARS-CoV-2 infection and progress of COVID-19 disease, it is becoming evident that both pathogen and host genetic factors are important too. In this study, we report findings from whole-exome sequencing (WES) of 27 individuals who died due to COVID-19, especially focusing on frequencies of DNA variants in genes previously associated with the SARS-CoV-2 infection and the severity of COVID-19.
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- The Ministry of Health in Slovakia created a genomics surveillance workgroup to monitor SARS-CoV-2 using whole-genome sequencing (WGS) during the pandemic.
- A total of 33,024 SARS-CoV-2 isolates were sequenced from March 2021 to March 2022, with the majority successfully deposited in the GISAID database.
- The study identified four variants of concern (Alpha, Beta, Delta, and Omicron) and documented their prevalence during three major waves of infections in Slovakia.