Vaccine-induced neutralizing antibodies bind to the H protein of a historical measles virus.

Measles is a highly contagious airborne viral disease. It can lead to serious complications and death and is preventable by vaccination. The live-attenuated measles vaccine (LAMV) derived from a measles virus (MV) isolated in 1954 has been in use globally for six decades and protects effectively by providing a durable humoral and cell-mediated immunity.

Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic.

The 1918 influenza pandemic was the deadliest respiratory pandemic of the 20th century and determined the genomic make-up of subsequent human influenza A viruses (IAV). Here, we analyze both the first 1918 IAV genomes from Europe and the first from samples prior to the autumn peak. 1918 IAV genomic diversity is consistent with a combination of local transmission and long-distance dispersal events.

Measles virus and rinderpest virus divergence dated to the sixth century BCE.

Many infectious diseases are thought to have emerged in humans after the Neolithic revolution. Although it is broadly accepted that this also applies to measles, the exact date of emergence for this disease is controversial. We sequenced the genome of a 1912 measles virus and used selection-aware molecular clock modeling to determine the divergence date of measles virus and rinderpest virus.

[Amyloidoses in the Berlin Museum of Medical History of the Charité].

The Berliner Medizinhistorische Museum (Berlin Museum of Medical History) of the Charité is located in its own separate building and was officially opened in 1899. It currently houses 10,000 specimens, of which 23 were labelled with the diagnosis "amyloid" or "amyloidosis". In this retrospective study we aimed to histologically verify the diagnosis, classify the amyloid deposits immunohistochemically and correlate the type of amyloid with clinico-pathological data.

Tracing life: the history, concept and goals of the new permanent exhibition in the Berlin Museum of Medical History at the Charité.

The Berlin Museum of Medical History at the Charité has been in existence since 1998. The institution aims to showcase medicine, yet it wants to show not only what medicine is but also and especially, how medicine came to be what it represents today. In its new permanent exhibition, opened on 25 October 2007, the museum takes a look at the development of medicine from a western, natural historical and scientific perspective over the last three centuries.