Electromyography- and Bioimpedance-Based Detection of Swallow Onset for the Control of Dysphagia Treatment.

Several studies support the benefits of biofeedback and Functional Electrical Stimulation (FES) in dysphagia therapy. Most commonly, adhesive electrodes are placed on the submental region of the neck to conduct Electromyography (EMG) measurements for controlling gamified biofeedback and functional electrical stimulation. Due to the diverse origin of EMG activity at the neck, it can be assumed that EMG measurements alone do not accurately reflect the onset of the pharyngeal swallowing phase (onset of swallowing).

Rare events model of the MBSAQIP database: risk of early bowel obstruction following metabolic surgery.

Background: Early small bowel obstruction (eSBO) (within 30-days) is a rare but important complication that is associated with high rates of morbidity, including readmission, reintervention, and reoperation.

Objectives: To identify patient-specific and operation-specific characteristics that predispose patients to eSBO and to identify at-risk individuals preoperatively.

Setting: 2015-2021 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP).

Bioinformatics Core Workflow for ChIP-Seq Data Analysis.

Chromatin immunoprecipitation (ChIP) followed by next-generation sequencing (-seq) has been the most common genomics method for studying DNA-protein interactions in the last decade. ChIP-seq technology became standard both experimentally and computationally. This chapter presents a core workflow that covers data processing and initial analytical steps of ChIP-seq data.

Direct neuronal reprogramming of mouse astrocytes is associated with multiscale epigenome remodeling and requires Yy1.

Direct neuronal reprogramming is a promising approach to regenerate neurons from local glial cells. However, mechanisms of epigenome remodeling and co-factors facilitating this process are unclear. In this study, we combined single-cell multiomics with genome-wide profiling of three-dimensional nuclear architecture and DNA methylation in mouse astrocyte-to-neuron reprogramming mediated by Neurogenin2 (Ngn2) and its phosphorylation-resistant form (PmutNgn2), respectively.