Publications by authors named "T Schaap"
Introduction: Alzheimer's Disease Neuroimaging Initiative (ADNI) has been pivotal in identifying and refining Alzheimer's disease (AD) biomarkers for clinical trials. This study leverages longitudinal data from participants who have progressed to amyloid-positivity during their study participation to track evolution of biomarkers and cognitive function.
Methods: We modeled AD biomarker (positron emission tomography [PET], structural, cerebrospinal fluid [CSF], cognition) trajectories before and after observed amyloid-positivity onset time to detect time at which each biomarker had detectable trajectory changes.
Objective: To estimate the incidence of uterine rupture in the Netherlands and evaluate risk indicators prelabour and during labor of women with adverse maternal and/or perinatal outcome.
Methods: This is a population-based nationwide study using the Netherlands Obstetrics Surveillance System (NethOSS). We performed a two-year registration of pregnant women with uterine rupture.
Article Synopsis
- The study investigates the incidence and clinical features of high neuraxial block during obstetric anesthesia in the Netherlands, an area with fewer anesthesiologists present in delivery units.
- Between November 2019 and May 2022, the research identified 5 cases of high neuraxial block that required tracheal intubation, revealing an estimated incidence of 1 in 29,770 neuraxial procedures.
- All patients involved were successfully extubated post-operation without needing intensive care, and there were no cases of cardiac arrest resulting from the incidents.
Early At-Home Measurement of Adalimumab Concentrations to Guide Anti-TNF Precision Dosing: A Pilot Study.
Eur J Drug Metab Pharmacokinet
July 2023
Article Synopsis
- Adalimumab underdosing can lead to ineffective treatment for rheumatic and inflammatory bowel diseases, prompting a study to forecast its concentrations early in therapy using population pharmacokinetic modeling.
- A literature search identified pharmacokinetic models, and patient samples were analyzed to predict steady state levels of adalimumab after the first dose, evaluating predictive performance through error metrics.
- The study included 36 patients, showing a 75% concordance between predicted and actual drug levels, and confirmed that early measurements can effectively predict future drug concentrations during treatment initiation.
Objective: To evaluate the incidence, diagnostic management strategies and clinical outcomes of women with spontaneous haemoperitoneum in pregnancy (SHiP) and reassess the definition of SHiP.
Design: A population-based cohort study using the Netherlands Obstetric Surveillance System (NethOSS).
Setting: Nationwide, the Netherlands.