Publications by authors named "T Scales"
Background: Amino acids are critical to tumor survival. Tumors can acquire amino acids from the surrounding microenvironment, including the serum. Limiting dietary amino acids is suggested to influence their serum levels.
View Article and Find Full Text PDFBackground: Amino acids are critical to tumor survival. Tumors can acquire amino acids from the surrounding microenvironment, including the serum. Limiting dietary amino acids is suggested to influence their serum levels.
View Article and Find Full Text PDFArticle Synopsis
- Cells depend on antioxidants like glutathione (GSH) for survival, with its production controlled by the enzyme GCLC.
- GSH is crucial for maintaining lipid levels in the liver, a key site for lipid production, and its deficiency affects fat storage and triglyceride levels.
- The study reveals that GSH influences lipid abundance by regulating the transcription factor NRF2, linking antioxidant function to lipid metabolism.
Article Synopsis
- - Cells depend on antioxidants like glutathione (GSH) for survival, with GSH being the most abundant antioxidant regulated by the enzyme GCLC.
- - A study involving the deletion of GSH in adult animals revealed its crucial role in maintaining lipid levels, particularly in the liver, which is key for lipid production.
- - The absence of GSH led to decreased expression of lipogenic enzymes, lower triglyceride levels, and reduced fat stores, highlighting GSH's role in balancing oxidative stress and lipid production through the repression of the transcription factor NRF2.