Burn injuries represent a significant problem in clinical practice due to the high risk of infection and the prolonged healing process. Recently, more attention has been given to natural remedies such as water extracts of various medicinal plants, which possess anti-inflammatory and wound healing properties. The aim of this study is to evaluate the efficacy and safety of L.
View Article and Find Full Text PDFIdiopathic pulmonary fibrosis remains a relevant problem of the healthcare system with an unfavorable prognosis for patients due to progressive fibrous remodeling of the pulmonary parenchyma. Starting with the damage of the epithelial lining of alveoli, pulmonary fibrosis is implemented through a cascade of complex mechanisms, the crucial of which is the TGF-β/SMAD-mediated pathway, involving various cell populations. Considering that a number of the available drugs (pirfenidone and nintedanib) have only limited effectiveness in slowing the progression of fibrosis, the search and justification of new approaches aimed at regulating the immune response, cellular aging processes, programmed cell death, and transdifferentiation of cell populations remains relevant.
View Article and Find Full Text PDFIn the article the biography of famous Italian doctor and anatomist Lorenzo Bellini who in his student years described a tubule system in the kidneys is reviewed. An authors translation of fragments of his work "Exercitatio anatomica de structura et usu renum" with the description of the discovery as well as the works of Marcello Malpighi "Opera posthuma", which stated the priority of this discovery to Bellini and not to Bartolomeo Eustachi, is provided. The evaluation of the medical and scientific activities of Bellini by his contemporaries is given.
View Article and Find Full Text PDFNowadays the number of patients diagnosed with helminthiases shows tendency for steady growth around the world. During last few years, researches in the field of immunology have again turned their attention towards the question of parasitological immunity and tissue response. Helminthiases and other parasitic diseases in some instances can induce central nervous system disorders and violate human behavioral reactions.
View Article and Find Full Text PDFPatol Fiziol Eksp Ter
January 2018
The Purpose: The purpose of research is to study cardiocytoprotective effect of cytoflavin in terms of aperinatal hypoxia in experiment.
Methods: During research the offspring (22 pups) of 15 females of white Wistar line rats aged 3-4 months were involved. The hypoxia was recreated by daily intraperitoneal introduction of sodium nitrite (NaNO2) in a dose of 5 mg/100 g of the body weight causing a moderately severe hypoxia.