A portrait of germline pathogenic variants in high and moderate penetrance breast cancer genes in Brazil.

Introduction: The prevalence of germline pathogenic/likely pathogenic variants (P/LP) in high and moderate penetrance (HMP) genes is approximately 7%-10% among breast cancer (BC) patients. The prevalence and spectrum of BC P/LP variants are affected by several factors. There are limited genetic data from Brazilian patients with BC.

Critical Crossroads: The Vital Role of Timely Diagnosis in Severe Amyopathic Dermatomyositis.

Clinically amyopathic dermatomyositis (CADM) is an uncommon subtype of dermatomyositis (DM) characterized by the typical cutaneous manifestations of DM but without clinical or enzymatic signs of muscle inflammation. We report a case of a 61-year-old woman with a four-week history of dry cough, myalgias, chills, pleuritic chest pain, and worsening shortness of breath. She also had a five-year history of inflammatory polyarthralgia.

Tumefactive Multiple Sclerosis: The Lethal Chameleon.

Unlabelled: Tumefactive multiple sclerosis (TMS) is a rare variant of multiple sclerosis that presents with a large demyelinating lesion in the central nervous system, accompanied by peripheral ring-like enhancement, perilesional oedema and mass effect. We report a case of a 59-year-old woman who was admitted to the hospital with a four-day history of somnolence, muscle weakness in her left extremities and ultimately, loss of consciousness. Over the following 48 hours, the patient's condition worsened with progressive consciousness impairment.

Turmeric essential oil improves intestinal integrity, immunological parameters, and performance of broiler chickens under cyclic heat stress.

This study aimed to examine whether dietary supplementation of broiler chickens with turmeric essential could mitigate the effects of cyclic heat stress conditions. Intestinal and immunological parameters and gene expression were evaluated during the grower phase. A total of 320 21-day-old male Cobb 500 broilers were distributed according to a completely randomized design with a 4 (diet) × 2 (environment) factorial arrangement and eight replications of five birds each.