Publications by authors named "T Sanchez Tamayo"
Article Synopsis
- NanoCore is a user-friendly tool designed for genomic surveillance using Nanopore sequencing, enabling quick analysis of pathogen transmission in healthcare settings.* -
- It calculates and visualizes core-genome multilocus sequence typing distances directly from Nanopore reads and is compatible with Illumina data.* -
- NanoCore demonstrates efficiency and accuracy in comparing bacterial strains, providing results similar to established methods and can be installed easily as free software.*
Article Synopsis
- The study explores the challenge of tracing SARS-CoV-2 transmission chains due to missed contacts and how viral sequencing can help reconstruct these networks.
- An integrated genomic surveillance system was developed in collaboration with public health authorities, combining viral sequencing, cluster identification, contact tracing data, and a user-friendly dashboard for data analysis.
- The system effectively characterized viral outbreaks, identified infection clusters, and enhanced hospital infection control, demonstrating its potential for better monitoring and management of SARS-CoV-2 transmission.
The fibrotic response has evolutionary worked in tandem with the inflammatory response to facilitate healing following injury or tissue destruction as a result of pathogen clearance. However, excessive inflammation and fibrosis are key pathological drivers of organ tissue damage. Moreover, fibrosis can occur in several conditions associated with chronic inflammation that are not directly caused by overt tissue injury or infection.
View Article and Find Full Text PDFAims: This population-based study sought to extend knowledge on factors explaining regional differences in type 2 diabetes mellitus medication patterns in Germany.
Methods: Individual baseline and follow-up data from four regional population-based German cohort studies (SHIP [northeast], CARLA [east], HNR [west], KORA [south]) conducted between 1997 and 2010 were pooled and merged with both data on regional deprivation and regional health care services. To analyze regional differences in any or newer anti-hyperglycemic medication, medication prevalence ratios (PRs) were estimated using multivariable Poisson regression models with a robust error variance adjusted gradually for individual and regional variables.
Objective: The objective of this analysis is to compare people with prevalent type 2 diabetes, incident type 2 diabetes and without diabetes with respect to longitudinal change in health-related quality of life (HRQOL) when adjusting for baseline determinants of HRQOL.
Research Design And Methods: Primary baseline and follow-up data from three regional and one national population-based cohort studies in Germany were pooled for analysis. HRQOL was measured using physical and mental health summary scores (PCS and MCS) from the German version of the Short Form Health Survey with 36 or 12 items.