Publications by authors named "T Samuel"
Despite decades of improvements in cytotoxic therapy, the current standard of care for locally advanced pancreatic cancer (LAPC) provides, on average, only a few months of survival benefit. Stereotactic Body Radiation Therapy (SBRT), a technique that accurately delivers high doses of radiation to tumors in fewer fractions, has emerged as a promising therapy to improve local control of LAPC; however, its effects on the tumor microenvironment and hypoxia remain poorly understood. To explore how SBRT affects pancreatic tumors, we combined an orthotopic mouse model of pancreatic cancer with an intravital microscopy platform to visualize changes to the in vivo tumor microenvironment in real-time.
View Article and Find Full Text PDFBackground: Formula-fed preterm infants require nutrient-enriched formulas with optimized protein levels to support growth and neurodevelopment. The purpose of this study was to evaluate the safety, tolerability, and effectiveness of a new liquid two-staged formula system designed to provide tailored nutrition during hospital stay and after discharge.
Methods: Male and female very-low-birth-weight preterm infants (birth weight ≤1,500 g; gestational age ≤32 weeks) were recruited from three neonatal units in Poland and Slovakia in a prospective, open-label, interventional study.
Modelling the temporal trajectories of human milk components.
BMC Pregnancy Childbirth
November 2024
Article Synopsis
- This paper analyzes how human milk composition changes over time, focusing on the first four months after birth.
- The study uses a model that includes two phases: an initial short linear increase during colostrum and a longer phase where milk components stabilize.
- Results indicate that individual biological differences among mothers have a greater impact on milk composition than geographical location, suggesting specific sampling strategies for further research.
Among the most popular chemotherapeutic agents, irinotecan, regarded as a prodrug belonging to the camptothecin family that inhibits topoisomerase I, is widely used to treat metastatic colorectal cancer (CRC). Although immunotherapy is promising for several cancer types, only microsatellite-instable (~7%) and not microsatellite-stable CRCs are responsive to it. Therefore, it is important to investigate the mechanism of irinotecan function to identify cellular proteins and/or pathways that could be targeted for combination therapy.
View Article and Find Full Text PDFArticle Synopsis
- The study explores the use of ultrafast Z-spectroscopy (UFZ) MRI at 3T to assess oxidative phosphorylation (OXPHOS) in human skeletal muscle during exercise.
- UFZ MRI techniques were tested on five healthy participants, revealing significant changes in metabolic signals post-exercise, which were further refined through pH correction methods.
- Results indicate that UFZ MRI can effectively reduce acquisition time and provides reliable metrics for mitochondrial function, emphasizing the importance of pH correction for accurate OXPHOS measurement.