Publications by authors named "T Saluja"
Clinical trials are the most rigorous scientific and regulated method to investigate the safety and efficacy of vaccines or drugs in pre-licensure stage. Clinical trial design and implementation are complex, time-consuming and involves close engagement with country's regulatory authority, clinical trial sites, investigators, and the healthcare system. Over the past few decades, a significant number of clinical trials have been conducted in low- and middle-income countries (LMICs), particularly in resource-limited settings.
View Article and Find Full Text PDFBackground: Pediatric vaccine clinical trials are crucial for evaluating and ensuring the safety and efficacy of new vaccines for children. However, in low-resource settings like Nepal, where clinical trials are relatively new, recruitment and retention of participants are challenging particularly due to diverse parental backgrounds, motivations and concerns. As such, parental motivations, perceived barriers, and experiences of participating in pediatric vaccine trial in Nepal, which hasn't previously been explored, needs to be understood.
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- Clinical trials (CT) are essential for developing new medicines and require participant involvement, which is influenced by their attitudes and understanding of the trials.
- A study at B.P. Koirala Institute of Health Sciences in Nepal assessed the knowledge and perceptions of 622 participants in a phase III CT, finding that a vast majority were literate, of indigenous backgrounds, and had not participated in a CT before.
- Results showed that 91% of participants had adequate knowledge and 95.7% had a positive perception of CT, with most joining for disease protection and believing the trials benefit humanity, suggesting the need for future studies on knowledge before and after participation.
Background: In October, 2017, WHO launched a strategy to eliminate cholera by 2030. A primary challenge in meeting this goal is the limited global supply capacity of oral cholera vaccine and the worsening of cholera outbreaks since 2021. To help address the current shortage of oral cholera vaccine, a WHO prequalified oral cholera vaccine, Euvichol-Plus was reformulated by reducing the number of components and inactivation methods.
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- Exposure to bushfire smoke, which contains harmful particulate matter, is linked to an increased risk of cerebrovascular diseases, such as stroke, but there's limited data on how patients with these conditions respond to such exposure.
- The study analyzed hospital admission data from the Hunter New England Local Health District during the 2019-20 bushfire season versus a control period in 2018-19, using specific statistical models to assess the impact of high smoke days on hospitalizations.
- Results showed 275 cerebrovascular admissions were recorded, with a slight increase during the bushfire season (147 vs. 128), but no significant overall rise in daily admissions was established.