Publications by authors named "T Sallam"
Adipose tissue regulates energy homeostasis and metabolic function, but its adaptability is impaired in obesity. In this study, we investigate the impact of acute PPARγ agonist treatment in obese mice and find significant transcriptional remodeling of cells in the stromal vascular fraction (SVF). Using single-cell RNA sequencing, we profile the SVF of inguinal and epididymal adipose tissue of obese mice following rosiglitazone treatment and find an induction of ribosomal factors in both progenitor and preadipocyte populations, while expression of ribosomal factors is reduced with obesity.
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- Ear infections, particularly otitis media (OM) and otitis externa (OE), can lead to serious complications and hearing loss, with this study analyzing the pathogens involved in these infections in patients at King Fahad Hospital in Saudi Arabia from January 2019 to June 2023.
- Among the 307 patients studied, 81.1% had detectable infections, predominantly bacterial (58%), followed by fungal (23.1%), and a notable number of cases (33%) were caused by methicillin-resistant Staphylococcus aureus (MRSA).
- The majority of OM cases were found in children, while OE was more variable in pathogen identification, highlighting that bacterial infections were the primary cause in OM, whereas fungi were more
Article Synopsis
- * The study reveals that hepatocytes are the main producers of lipopolysaccharide binding protein (LBP), which is implicated in liver inflammation but does not significantly affect liver fibrosis.
- * Research indicates that targeting inflammation through LBP might not effectively reduce liver fibrosis, challenging the current strategies aimed at managing MAFLD.