Publications by authors named "T Sakuragi"
Despite the high frequency of pregnancies complicated by abnormal glucose metabolism associated with obesity, methylmercury (MeHg) metabolism in pregnant women with abnormal glucose metabolism is unclear. We aimed to elucidate the MeHg tissue distribution in obese female mice with abnormal glucose metabolism and their fetuses. Female C57BL/6J mice were fed a high-fat diet (HFD) or a standard diet (Ctrl) for 12 weeks and mated.
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- The study aimed to investigate why pregnant women with glucose intolerance often have large infants, focusing on amino and fatty acid transport in the placenta, beyond just glucose transport.
- Researchers analyzed postpartum placental tissues from 101 eligible deliveries, finding higher expression levels of certain transporters (LAT1 and placenta-FABPpm) in women with glucose intolerance compared to those without.
- The results suggest that, despite controlled blood sugar levels, managing other nutrients like amino acids and fatty acids in glucose-intolerant pregnancies is crucial for fetal growth.
The coronavirus disease 2019 (COVID-19) pandemic forced people to change their lifestyles. We examined dietary differences by job type and industry among workers during the pandemic. This cross-sectional study was conducted using data an internet survey.
View Article and Find Full Text PDFBackground: Lifelong health is dependent on prenatal growth and development, influenced by the placental intrauterine environment. Charged with dual functions--exchange of oxygen and nutrients as well as a barrier against toxins--the placenta itself is susceptible to environmental exposure to heavy metals.
Objective: To examine the use of placenta weight as a biomarker for heavy metal exposure using a large Japanese cohort of pregnant women.
XK-related 8 (XKR8), in complex with the transmembrane glycoprotein basigin, functions as a phospholipid scramblase activated by the caspase-mediated cleavage or phosphorylation of its C-terminal tail. It carries a putative phospholipid translocation path of multiple hydrophobic and charged residues in the transmembrane region. It also has a crucial tryptophan at the exoplasmic end of the path that regulates its scrambling activity.
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