Publications by authors named "T Sakoda"
Background: Chronic diseases such as diabetes and cardiovascular disease are global health challenges, affecting millions of people worldwide. Traditional health care often falls short in chronic disease management. This has led to the exploration of innovative solutions, such as mobile health (mHealth) technologies.
View Article and Find Full Text PDFIn this study, we investigated the measurable residual leukemic stem cell (MR-LSC) population after allogeneic stem cell transplantation (allo-SCT) for high-risk acute myeloid leukemia (AML), utilizing T-cell immunoglobulin mucin-3 (TIM-3) expression as a functional marker of AML leukemic stem cells (LSCs). Analysis of the CD34CD38 fraction of bone marrow cells immediately after achievement of engraftment revealed the presence of both TIM-3LSCs and TIM-3 donor hematopoietic stem cells (HSCs) at varying ratios. Genetic analysis confirmed that TIM-3 cells harbored patient-specific mutations identical to those found in AML clones, whereas TIM-3 cells did not, indicating that TIM-3CD34CD38 cells represent residual AML LSCs.
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- Chronic kidney disease (CKD) often goes unnoticed early on but can lead to serious cardiovascular and kidney complications, making early detection essential for better health outcomes.
- This study focused on developing a prediction model to identify Japanese individuals with mild CKD who are at risk for hospitalization due to ischemic heart disease (IHD) or cerebrovascular disease (CVD), using data from a large cohort.
- The findings indicate significant predictors like age, sex, and comorbidities, and the model showed a good predictive ability, providing a valuable tool for healthcare providers to stratify patients and implement timely interventions.
Article Synopsis
- Immunomodulatory drugs (IMiDs) are important treatments for myeloma and myelodysplastic syndrome, but they increase the risk of thrombosis, which can lead to serious complications.
- This study explored how IMiDs affect thrombosis by examining cereblon substrates in human megakaryocytes, finding that thrombospondin-1 (THBS-1) accumulates abnormally when IMiDs interfere with its degradation.
- The results indicate that the accumulation of THBS-1, caused by disrupted cereblon interaction due to IMiDs, may contribute to the increased risk of thromboembolism in patients undergoing IMiD treatment.
Hypertension and insulin resistance are established risk factors for chronic kidney disease. However, the association between chronic kidney disease and insulin resistance in detailed hypertension pattern groups such as isolated diastolic hypertension remains unclear. Triglyceride-glucose index has been noted as an indicator of insulin resistance.
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