Publications by authors named "T Sainio"
Background And Objective: Toxicity from local salvage therapy for radiorecurrent prostate cancer (PCa) remains a concern. This phase 2 study evaluates the outcomes of salvage magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (sTULSA).
Methods: Men with biochemically relapsed, biopsy-proven PCa following definitive radiotherapy underwent whole- or partial-gland sTULSA (NCT03350529).
Large multi-site studies that combine magnetic resonance imaging (MRI) data across research sites present exceptional opportunities to advance neuroscience research. However, scanner or site variability and non-standardised image acquisition protocols, data processing and analysis pipelines can adversely affect the reliability and repeatability of MRI derived brain measures. We implemented a standardised MRI protocol based on that used in the Adolescent Brain Cognition Development (ABCD) study in two sites, and across four MRI scanners.
View Article and Find Full Text PDFPurpose: Magnetic resonance - high-intensity focused ultrasound (MR-HIFU) is a noninvasive treatment option for symptomatic uterine leiomyomas. Currently, pretreatment MRI is used to assess tissue characteristics and predict the most likely therapeutic response for individual patients. However, these predictions still entail significant uncertainties.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the non-perfused volume (NPV) changes following heat-based prostate ablation therapy in patients with benign prostatic hyperplasia (BPH), primary prostate cancer (PCa), and radiorecurrent PCa.
- Results show significant differences in NPV reduction among the groups at three and six months, with BPH showing a notable decrease while radiorecurrent PCa's NPV slightly increased.
- The findings indicate that necrotic tissue resolution is slower in previously irradiated tissue, which may contribute to increased treatment toxicity, but by 12 months, most necrotic tissue had resolved across all groups.