Publications by authors named "T Saikawa"

Article Synopsis
  • Metal-organic frameworks (MOFs) are porous materials made from metal ions and organic ligands, which show potential for capturing CO from the air.
  • The study developed a regression model to predict how different components of MOFs affect their capacity to adsorb CO, using a combination of experimental and structural data.
  • By applying topological data analysis through persistence diagrams, the researchers were able to assess the impact of the MOF's geometric structure on CO adsorption efficiency, finding strong correlation with experimental results, which could help identify optimized MOF structures.
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Background: Higher cholesterol absorption has been reported to be related to a higher incidence of cardiovascular events (CVEs). The KEEP (Kyushu Elderly Ezetimibe Phytosterol) study, a substudy of the EWTOPIA 75 (Ezetimibe Lipid-Lowering Trial on Prevention of Atherosclerotic Cardiovascular Disease in 75 or Older) study, investigated the relationships of cholesterol absorption and synthesis markers with CVEs in older old individuals with hypercholesterolemia, particularly in relation to ezetimibe treatment.

Methods And Results: Eligible patients were those aged ≥75 years who had low-density lipoprotein cholesterol ≥140 mg/dL, no history of coronary artery disease, and no recent use of lipid-lowering drugs.

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This article addresses an optimisation problem of distributing rapid diagnostic kits among patients when the demands far surpass the supplies. This problem has not been given much attention in the field, and therefore, this article aims to provide a preliminary result in this problem domain. First, we describe the problem and define the goal of the optimisation by introducing an evaluation metric that measures the efficiency of the distribution strategies.

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Article Synopsis
  • * An experimental model revealed that AF susceptibility increased 8 hours after binge drinking, due to heightened activity of T-type calcium channels (TCCs) and changes in specific transcription factors linked to heart function.
  • * The findings suggest that ethanol activates certain cellular pathways involving protein kinase C (PKC) and glycogen synthase kinase 3β (GSK3β), which contribute to the increased risk of AF following binge drinking, shedding light on the mechanisms behind this condition.
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