Publications by authors named "T Saha"
The Wnt/β-catenin signalling pathway normally maintains cellular and tissue homeostasis by regulating cellular differentiation and survival in a controlled manner. An aberrantly regulated Wnt/β-catenin signalling pathway can transform into an oncogenic pathway, which is associated with Colorectal cancer (CRC) as well as other cancers. CRC is one of the most frequently occurring gastrointestinal cancers worldwide.
View Article and Find Full Text PDFThe establishment of protective immune responses relies on the ability of terminally differentiated B cells to secrete a broad variety of antigen-specific antibodies with different effector functions. RIF1 is a multifunctional protein that promotes antibody isotype diversification via its DNA end protection activity during class switch recombination. In this study, we showed that RIF1 ablation resulted in increased plasmablast formation ex vivo and enhanced terminal differentiation into plasma cells upon immunization.
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- All-solid-state lithium-ion batteries (ASSLBs) are poised to enhance the performance and safety of next-generation electronics, especially electric vehicles, by utilizing solid electrolytes with high ionic conductivity.
- Researchers have substituted the B-site of LiLaTiO (LLTO) with Ga to create Ga-doped LLTO solid electrolytes, leading to structural improvements, enhanced ionic conductivity, and better electrochemical stability through a solid-state reaction method.
- The results show that Ga-doped LLTO exhibits a significantly increased ionic conductivity of 4.15 × 10 S cm in LiLaTiGaO (with 3% Ga), making it a promising candidate for future ASSLB applications due to its stable operating voltage range.
The biological production of lipids presents a sustainable method for generating fuels and chemicals. Recognized as safe and enhanced by advanced synthetic biology and metabolic engineering tools, yeasts are becoming versatile hosts for industrial applications. However, lipids accumulate predominantly as triacylglycerides in yeasts, which are suboptimal for industrial uses.
View Article and Find Full Text PDFNatural products have perennially served as a cornerstone for the genesis of novel medicinal compounds. Most clinical therapeutics originate from ancestral herbal remedies and their formulations. Scholars and practitioners have always aimed to extract better remedies to treat various ailments.
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