Publications by authors named "T SOMA"
Objectives: To assess the quality of life in Japanese patients with Fuchs endothelial corneal dystrophy (FECD) using The National Eye Institute Visual Function Questionnaire.
Methods: Here, 34 patients with FECD (FECD group) and 13 healthy individuals (control group) completed the National Eye Institute Visual Function Questionnaire Japanese version by interview format. The association between dominant eye corrected distance visual acuity and composite score (component 11) or subscales in the FECD group was evaluated using Spearman rank correlation coefficient.
Article Synopsis
- Eosinophil inflammation in severe asthma often persists despite high-dose corticosteroid treatment, leading to the development of biologics targeting type 2 cytokines for corticosteroid-resistant cases.* -
- This study investigated the direct effects of type 2 cytokines (IL-4, IL-5, IL-13, TSLP) on eosinophils from healthy individuals, measuring indicators like adhesiveness and superoxide production.* -
- Results indicated that IL-5 significantly enhanced eosinophil functions, whereas IL-4, IL-13, and TSLP did not show such direct effects at clinical concentrations, implying limited eosinophil involvement in the action of certain biologics.*
Background: The loss of corneal epithelial stem cells from the limbus at the edge of the cornea has severe consequences for vision, with the pathological manifestations of a limbal stem-cell deficiency (LSCD) difficult to treat. Here, to the best of our knowledge, we report the world's first use of corneal epithelial cell sheets derived from human induced pluripotent stem cells (iPSCs) to treat LSCD.
Methods: This non-randomised, single-arm, clinical study involved four eyes of four patients with LSCD at the Department of Ophthalmology, Osaka University Hospital.
Introduction: Nociplastic pain (NP), a third category of chronic pain, offers a framework for elucidating its pathophysiology and treatment strategies. One of the characteristics of NP is comorbidity of symptoms other than pain, such as psychological and cognitive problems; therefore, these can be clues to understanding NP. Recently, we reported several cases with comorbid symptoms of attention-deficit/hyperactivity disorder (ADHD).
View Article and Find Full Text PDFIntervention for impending pathological fractures at proximal femur is associated with lower mortality rates in patients with intermediate-to-high risk according to the Katagiri-New score.
BMC Musculoskelet Disord
October 2024
Article Synopsis
- Prophylactic surgery for impending fractures in patients with long-bone metastasis is linked to better survival rates compared to those with complete fractures, especially in those deemed intermediate-to-high risk.
- A study of 121 patients revealed lower one-year mortality rates for those with impending fractures, alongside higher rates of home discharge and improved post-operative mobility.
- Results indicated that the type of surgical intervention (nailing vs. hemiarthroplasty) did not significantly affect survival rates among patients with impending fractures.