Publications by authors named "T SHIMOMURA"
Background: Despite the availability of advanced imaging technologies, it remains difficult to achieve sufficient staging accuracy to ensure a tailored treatment strategy for patients with upper tract urothelial carcinoma (UTUC). The aim of the study was to identify preoperative risk factors for tumor upstaging in patients with UTUC initially staged as clinical T2 or lower and to analyze these factors separately for renal pelvic cancer and ureteral cancer.
Methods: This retrospective study included data from patients with UTUC who underwent nephroureterectomy.
Background Gastroesophageal reflux disease (GERD) is a condition characterized by reflux of gastric contents, leading to damage to the esophageal mucosa and/or unpleasant symptoms, with a global prevalence of 13%. Although acid-suppressive medications are currently the most effective treatments for GERD, they may be ineffective against its symptoms. We therefore investigated the efficacy of a physical exercise program for the treatment of intractable GERD symptoms.
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- * A case study highlights a very elderly patient with dementia and atrial fibrillation who developed recurrent thrombosis, complicating the management due to his multiple health issues.
- * The report emphasizes the need for physicians to consider age-related factors like cognitive impairment and frailty to tailor treatment goals and improve health outcomes while reducing risks in older patients with complex conditions.
Article Synopsis
- The study evaluated the effectiveness and safety of three androgen receptor pathway inhibitors (ARPI) — abiraterone, enzalutamide, and apalutamide — in treating patients with metastatic hormone-sensitive prostate cancer in a real-world setting.
- Records of 668 high-risk patients treated with these drugs were analyzed, comparing prostate-specific antigen (PSA) responses, overall survival, and the incidence of adverse events.
- Results showed no significant differences in overall survival or cancer-specific survival among the three drugs, although abiraterone demonstrated a higher rate of achieving a 99% PSA decline, and enzalutamide had the lowest treatment discontinuation rates.
Article Synopsis
- Renal cell carcinoma (RCC) can spread to unusual sites, with a rare case reported of metastasis to the area behind the seminal vesicles in a 44-year-old male patient with clear cell RCC.
- After identifying the metastases during follow-up post-surgery, the patient underwent a unique treatment combining immune-oncology therapy and tyrosine kinase inhibitors (IO-TKI) that effectively reduced the lesions.
- The subsequent laparoscopic surgery removed all metastases, which were confirmed as clear cell RCC, and no further disease progression was observed two months after the operation, showcasing this treatment's potential for atypical metastatic cases.