Prevalence, Patient Characteristics, and Treatment of Patients with Hypertrophic Cardiomyopathy: A Nationwide Payer Database Study.

Introduction: Data on the prevalence of hypertrophic cardiomyopathy (HCM), characteristics of patients with HCM, and treatment patterns in Japan are limited. This study aimed to estimate the prevalence of HCM and describe the patient characteristics, treatment patterns, and utilization of medical expense subsidies in Japan, using payer claims data from insurers.

Methods: This retrospective study of patients with HCM in Japan utilized payer claims data from insurers (Advanced Elderly Medical Service System [AEMSS], Kokuho, and Kempo) from January 1, 2017, to December 31, 2021.

Removable dialkoxybenzyl linker for enhanced HPLC purification of peptide hydrazides.

High-performance liquid chromatography (HPLC) plays a crucial role in purifying peptides and proteins and monitoring their reactions. Peptide hydrazides are widely employed intermediates in modern peptide/protein chemistry. However, they often exhibit peak tailing during HPLC purification and analysis.

Radiomics and dosiomics approaches to estimate lung function after stereotactic body radiation therapy in patients with lung tumors.

Lung function assessment is essential for determining the optimal treatment strategy for radiation therapy in patients with lung tumors. This study aimed to develop radiomics and dosiomics approaches to estimate pulmonary function test (PFT) results in post-stereotactic body radiation therapy (SBRT). Sixty-four patients with lung tumors who underwent SBRT were included.

Histochemical analysis of osteoclast and osteoblast distributions on hydroxyapatite/collagen bone-like nanocomposite embedded in rat tibiae.

Objectives: Hydroxyapatite (HAp)/collagen (Col) cylinders with laminated collagen layers were implanted into the tibial diaphysis of rats and examined histochemically to clarify how the orientation of HAp and Col bone-like nanocomposite fibers in HAp/Col blocks affects bone resorption and formation.

Methods: HAp/Col fibers were synthesized and compressed into cylindrical blocks to mimic bone nanostructures. These were implanted into the cortical bone cavities of 10-week-old male Wistar rats with fiber bundles parallel to the tibial surface.

Optical Imaging of Trigeminal Ganglion Excitation Evoked by Electrical Stimulation of the Trigeminal Nerve.

Background There are many reports of anatomical and physiological studies on trigeminal ganglion neurons, but few studies have analyzed temporal changes in the excitation of the trigeminal ganglion. This study aimed to establish an experimental system for spatial and temporal imaging analysis of the excitatory dynamics of trigeminal ganglion cells evoked by stimulation of a peripheral branch of the trigeminal nerve. Methods After excision of the trigeminal ganglion with the inferior alveolar nerve (IAN) from Sprague Dawley rats (seven to nine weeks old), 400-µm-thick slices of the trigeminal ganglion with the IAN were prepared.