Inside Ceramics and Between MgO Grains: Solid-State Synthesis of Intergranular Semiconducting or Magnetic Spinels.

Configurations of composite metal oxide nanoparticles are typically far off their thermodynamic equilibrium state. As such they represent a versatile but so far overlooked source material for the intergranular solid-state chemistry inside ceramics. Here, it is demonstrated how the admixture of Fe and In ions to MgO nanoparticles, as achieved by flame spray pyrolysis, can be used to engage ion exsolution, phase separation, and subsequent spinel formation inside the network of diamagnetic and insulating MgO grains.

Smooth muscle cell phenotypic switching occurs independent of aortic dilation in bicuspid aortic valve-associated ascending aortas.

Background: Bicuspid aortic valves (BAV) are frequently associated with ascending aortic aneurysms. The etiology is incompletely understood, but genetic factors, in addition to flow perturbations, are likely involved. Since loss of contractility and elaboration of extracellular matrix in the vessel wall are features of BAV-associated aortopathy, phenotypic modulation of smooth muscle cells (SMCs) may play a role.

Predicting multimodal chromatography of therapeutic antibodies using multiscale modeling.

Multimodal chromatography has emerged as a powerful method for the purification of therapeutic antibodies. However, process development of this separation technique remains challenging because of an intricate and molecule-specific interaction towards multimodal ligands, leading to time-consuming and costly experimental optimization. This study presents a multiscale modeling approach to predict the multimodal chromatographic behavior of therapeutic antibodies based on their sequence information.

Nuclear Abnormalities in p.(Glu2Lys) Variant Segregating with -Associated Cardiocutaneous Progeria Syndrome.

The gene encodes lamin A and lamin C, which play important roles in nuclear organization. Pathogenic variants in cause laminopathies, a group of disorders with diverse phenotypes. There are two main groups of disease-causing variants: missense variants affecting dimerization and intermolecular interactions, and heterozygous substitutions activating cryptic splice sites.