Nimbolide attenuates hepatocellular carcinoma by regulating miRNAs 21, 145 and 221 and their target gene expression.

Background And Aims: MicroRNAs (miRNAs) are becoming progressively emerging in cancer research from an etiologic and curative point of view. Several miRNAs act as oncogenes or tumor suppressors, which are dysregulated in numerous cancers. Our previous studies have established that nimbolide (a bioactive terpenoid from neem) attenuated hepatocellular carcinoma (HCC) through various mechanisms in mice.

Vulnerability of mangrove ecosystems to anthropogenic marine litter along the southeast coast of India.

Human-caused marine pollution poses a constant threat to marine ecosystems, particularly tropical mangrove forests, which are vulnerable to litter from both inland and marine sources due to inadequate waste management. Despite well-documented effects of marine litter on various maritime habitats, its impact on mangrove forests remains underexplored. This study investigates the abundance, composition, sources, and impacts of human-caused marine litter on mangroves along the Thoothukudi coast in the Gulf of Mannar, southeast India.

Manganese doped two-dimensional zinc ferrite thin films as chemiresistive trimethylamine gas sensors.

Trimethylamine (TMA) is highly toxic and can have lethal effects on living organisms. Detecting the presence of TMA in air is very important because, if the TMA level exceeds the OSHA (Occupational Safety and Health Administration) limit, it may harm the environment and endanger human life. Doping is an appropriate flexible way to change the electrical structures of metal oxide semiconductors (MOSs) and improve their ability to detect toxic gases.

Candesartan cilexetil ameliorates NOSTRIN-NO dependent portal hypertension in cirrhosis and ACLF.

In decompensated cirrhosis, the severity of portal hypertension (PHT) is associated with increased hepatic endothelial nitric oxide synthase (eNOS) trafficking inducer (Nostrin), but the mechanism remains unclear. AIM: To investigate: (1) Whether in cirrhosis-PHT models, ± superimposed inflammation to mimic acute-on-chronic liver failure (ACLF) modulates hepatic nitric oxide synthase trafficking inducer (NOSTRIN) expression, nitric oxide (NO) synthesis, and/or endothelial dysfunction (ED); and (2) Whether the "angiotensin II type 1 receptor blocker" candesartan cilexetil (CC) affects this pathway. CD-1 mice received intraperitoneal carbon tetrachloride injections (CCl 15% v/v in corn oil, 0.

Assessing efficacy of instructor based orientation to donning doffing protocols and modifications to doffing area infrastructure in reducing SARS-CoV-2 infection among Doctors assigned to COVID-19 patient care.

Background: We assess the efficacy of orientation programmes for doctors of proper donning, doffing techniques for personal protective equipment (PPE) and safe practices inside the COVID-19 hospital in reducing the COVID-19 infection rate among doctors.

Methods: A total of 767 resident doctors and 197 faculty visits on weekly rotation were recorded over a six month period. Doctors were guided through orientation sessions before their entry into the COVID-19 hospital from 1 August 2020.