Publications by authors named "T S Randall"
Excess dietary salt and salt-sensitivity contribute to cardiovascular disease. Distinct T cell phenotypic responses to high salt and hypertension as well as influences from environmental cues are not well understood. The aryl hydrocarbon receptor (AhR) is activated by dietary ligands, promoting T cell and systemic homeostasis.
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- - Idiopathic pulmonary fibrosis (IPF) is a severe lung disease with no cure besides lung transplantation, and its mechanisms are not fully understood.
- - Research indicates that a deficiency in the innate immune receptor TLR5 increases the risk of IPF in humans and raises vulnerability to lung damage and fibrosis in mice; activating TLR5 protects against these issues.
- - The protective effects of TLR5 are linked to its role in promoting healthy microbial balance in the lungs, with disrupted microbiomes seen in both IPF patients and TLR5-deficient mice.
The prototypic IFN-inducible transcription factor, IRF1, not only controls inflammatory gene expression but also regulates T cell and macrophage fate specification and function. Using bone marrow chimeras (80% B6.129S2-Ighmtm1Cgn/J [µMT] + 20% B6.
View Article and Find Full Text PDFThe essential Drosophila RNA-binding protein Brain Tumor (Brat) represses specific genes to control embryogenesis and differentiation of stem cells. In the brain, Brat functions as a tumor suppressor that diminishes neural stem cell proliferation while promoting differentiation. Though important Brat-regulated target mRNAs have been identified in these contexts, the full impact of Brat on gene expression remains to be discovered.
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- Cervical cancer remains a significant health issue for women, particularly in low-resource areas, making follow-up care crucial for effective treatment monitoring and reducing health risks.
- A qualitative study in Uganda explored barriers to follow-up visits among patients and healthcare providers, revealing issues like long waiting times, lack of privacy, and insufficient male partner support as major challenges.
- Key facilitators identified included social support, positive self-esteem, and effective patient counseling, highlighting the need for targeted interventions to improve retention in cervical cancer care.